Identification of a molecular gating determinant within the carboxy terminal region of Ca
Cav3.3 channel
Electrophysiology
Gating
T-type channels
Journal
Molecular brain
ISSN: 1756-6606
Titre abrégé: Mol Brain
Pays: England
ID NLM: 101468876
Informations de publication
Date de publication:
08 04 2019
08 04 2019
Historique:
received:
24
02
2019
accepted:
01
04
2019
entrez:
10
4
2019
pubmed:
10
4
2019
medline:
1
8
2019
Statut:
epublish
Résumé
The physiological functions controlled by T-type channels are intrinsically dependent on their gating properties, and alteration of T-type channel activity is linked to several human disorders. Therefore, it is essential to develop a clear understanding of the structural determinants responsible for the unique gating features of T-type channels. Here, we have investigated the specific role of the carboxy terminal region by creating a series a deletion constructs expressed in tsA-201 cells and analyzing them by patch clamp electrophysiology. Our data reveal that the proximal region of the carboxy terminus contains a structural determinant essential for shaping several gating aspects of Ca
Identifiants
pubmed: 30961646
doi: 10.1186/s13041-019-0457-0
pii: 10.1186/s13041-019-0457-0
pmc: PMC6454634
doi:
Substances chimiques
CACNA1I protein, human
0
Calcium Channels, T-Type
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
34Subventions
Organisme : CIHR
Pays : Canada
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