Basal serum cortisol concentration in very low birth weight infants.
antenatal corticosteroid
cortisol
perinatal distress
premature infants
Journal
Pediatrics and neonatology
ISSN: 2212-1692
Titre abrégé: Pediatr Neonatol
Pays: Singapore
ID NLM: 101484755
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
19
11
2018
revised:
21
12
2018
accepted:
14
03
2019
pubmed:
10
4
2019
medline:
22
4
2020
entrez:
10
4
2019
Statut:
ppublish
Résumé
The aim of our study was to measure the basal serum cortisol concentration immediately after birth and to determine its association with perinatal factors and clinical outcomes in very low birth weight (VLBW) infants. Basal serum cortisol level was obtained within one hour after birth in inborn VLBW infants. The association between the basal serum cortisol level and perinatal and clinical outcomes was analyzed by comparing the groups with high versus low cortisol levels. In total, 80 infants were included. The median concentration of basal serum cortisol was 167 nmol/L with an interquartile range of 98-298 nmol/L. The basal serum cortisol concentration positively correlated with elapsed time from the last betamethasone dose. Low serum cortisol concentration was associated with antenatal corticosteroid therapy, low lactic acid level, and low leukocyte count at birth. Basal serum cortisol level was not associated with mortality and neonatal morbidities including hypotension and severe grade intraventricular hemorrhage. Both maternal corticosteroid therapy and perinatal distress may affect the basal serum cortisol concentration in VLBW infants early after birth.
Sections du résumé
BACKGROUND
The aim of our study was to measure the basal serum cortisol concentration immediately after birth and to determine its association with perinatal factors and clinical outcomes in very low birth weight (VLBW) infants.
METHODS
Basal serum cortisol level was obtained within one hour after birth in inborn VLBW infants. The association between the basal serum cortisol level and perinatal and clinical outcomes was analyzed by comparing the groups with high versus low cortisol levels.
RESULTS
In total, 80 infants were included. The median concentration of basal serum cortisol was 167 nmol/L with an interquartile range of 98-298 nmol/L. The basal serum cortisol concentration positively correlated with elapsed time from the last betamethasone dose. Low serum cortisol concentration was associated with antenatal corticosteroid therapy, low lactic acid level, and low leukocyte count at birth. Basal serum cortisol level was not associated with mortality and neonatal morbidities including hypotension and severe grade intraventricular hemorrhage.
CONCLUSION
Both maternal corticosteroid therapy and perinatal distress may affect the basal serum cortisol concentration in VLBW infants early after birth.
Identifiants
pubmed: 30962158
pii: S1875-9572(18)30756-3
doi: 10.1016/j.pedneo.2019.03.003
pii:
doi:
Substances chimiques
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
648-653Informations de copyright
Copyright © 2019. Published by Elsevier B.V.