Characterizing the Molecular Architecture of Cortical Regions Associated with High Educational Attainment in Older Individuals.
cognitive reserve
cortical thickness
gene expression
immune response
synaptic transmission
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
05 06 2019
05 06 2019
Historique:
received:
18
09
2018
revised:
18
02
2019
accepted:
08
03
2019
pubmed:
10
4
2019
medline:
23
6
2020
entrez:
10
4
2019
Statut:
ppublish
Résumé
Neuroimaging investigations have revealed interindividual variations in anatomy, metabolism, activity, and connectivity of specific cortical association areas through which years of education (YoE), as a common proxy of cognitive reserve, may operate in the face of age- or pathology-associated brain changes. However, the associated molecular properties of YoE-related brain regions and the biological pathways involved remain poorly understood. In the present study we first identified brain areas that showed an association between cortical thickness and YoE among 122 cognitively healthy older human individuals (87 female). We subsequently characterized molecular properties of these regions by studying brain-wide microarray measurements of regional gene expression. In accordance with previous studies, we observed that YoE were associated with higher cortical thickness in medial prefrontal, anterior cingulate, and orbitofrontal areas. Compared with the rest of the cortex, these regions exhibited a distinct gene expression profile characterized by relative upregulation of gene sets implicated in ionotropic and metabotropic neurotransmission as well as activation of immune response. Our genome-wide expression profile analysis of YoE-related brain regions points to distinct molecular pathways that may underlie a higher capacity for plastic changes in response to lifetime intellectual enrichment and potentially also a higher resilience to age-related pathologic brain changes.
Identifiants
pubmed: 30962275
pii: JNEUROSCI.2370-18.2019
doi: 10.1523/JNEUROSCI.2370-18.2019
pmc: PMC6554631
doi:
Banques de données
ClinicalTrials.gov
['NCT01634841']
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4566-4575Informations de copyright
Copyright © 2019 the authors.
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