Ability of bifidobacteria to metabolize chitin-glucan and its impact on the gut microbiota.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
08 04 2019
08 04 2019
Historique:
received:
27
11
2018
accepted:
22
03
2019
entrez:
10
4
2019
pubmed:
10
4
2019
medline:
7
10
2020
Statut:
epublish
Résumé
Chitin-glucan (CG) represents a natural carbohydrate source for certain microbial inhabitants of the human gut and may act as a prebiotic for a number of bacterial taxa. However, the bifidogenic activity of this substrate is still unknown. In the current study, we evaluated the ability of chitin-glucan to influence growth of 100 bifidobacterial strains belonging to those species commonly identified within the bifidobacterial communities residing in the infant and adult human gut. Such analyses were coupled with transcriptome experiments directed to explore the transcriptional effects of CG on Bifidobacterium breve 2L, which was shown to elicit the highest growth performance on this natural polysaccharide. In addition, an in vivo trial involving a rat model revealed how the colonization efficiency of this bifidobacterial strain was enhanced when the animals were fed with a diet containing CG. Altogether our analyses indicate that CG is a valuable novel prebiotic compound that may be added to the human diet in order to re-establish/reinforce bifidobacteria colonization in the mammalian gut.
Identifiants
pubmed: 30962486
doi: 10.1038/s41598-019-42257-z
pii: 10.1038/s41598-019-42257-z
pmc: PMC6453949
doi:
Substances chimiques
Glucans
0
Chitin
1398-61-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5755Références
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
Folia Microbiol (Praha). 2010 Jul;55(4):379-82
pubmed: 20680576
Biol Pharm Bull. 2003 Jun;26(6):902-4
pubmed: 12808311
Appl Environ Microbiol. 2007 Dec;73(23):7767-70
pubmed: 17933936
J Agric Food Chem. 2009 Feb 11;57(3):1093-8
pubmed: 19154104
Front Microbiol. 2017 Sep 12;8:1749
pubmed: 28955319
Mol Nutr Food Res. 2017 Jan;61(1):
pubmed: 27374808
Trends Microbiol. 2012 Oct;20(10):467-76
pubmed: 22902802
Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11217-22
pubmed: 21690406
Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19514-9
pubmed: 20974960
Nutrients. 2013 Apr 22;5(4):1417-35
pubmed: 23609775
Bioinformatics. 2010 Oct 1;26(19):2460-1
pubmed: 20709691
Nucleic Acids Res. 2013 Jan;41(Database issue):D590-6
pubmed: 23193283
FEMS Microbiol Ecol. 2016 Dec;92(12):
pubmed: 27604252
ISME J. 2016 Jul;10(7):1656-68
pubmed: 26859770
Trends Microbiol. 2018 Apr;26(4):339-350
pubmed: 29089173
Appl Environ Microbiol. 2005 Dec;71(12):8228-35
pubmed: 16332807
PLoS One. 2013 Jul 15;8(7):e68739
pubmed: 23869230
Sci Rep. 2016 May 11;6:25945
pubmed: 27166072
J Nutr Biochem. 2012 Jan;23(1):51-9
pubmed: 21411304
J Nutr. 1995 Jun;125(6):1401-12
pubmed: 7782892
ISME J. 2017 Dec;11(12):2834-2847
pubmed: 28837128
Nutrients. 2016 Aug 26;8(9):
pubmed: 27571098
J Sci Food Agric. 2014 Jan 30;94(2):163-8
pubmed: 23963950
Nature. 2011 May 12;473(7346):174-80
pubmed: 21508958
PLoS One. 2012;7(5):e36957
pubmed: 22606315
Carbohydr Polym. 2017 Jun 15;166:24-30
pubmed: 28385229
Prikl Biokhim Mikrobiol. 2012 May-Jun;48(3):340-5
pubmed: 22834307
Nat Methods. 2010 May;7(5):335-6
pubmed: 20383131
Bioinformatics. 2000 Oct;16(10):944-5
pubmed: 11120685
Appl Environ Microbiol. 2014 Jul;80(14):4414-26
pubmed: 24814790
BMC Microbiol. 2014 Nov 25;14:282
pubmed: 25420416
FEMS Microbiol Ecol. 2014 Nov;90(2):493-503
pubmed: 25117972
Sci Rep. 2015 Oct 28;5:15782
pubmed: 26506949