Modeling Parkinson's disease in midbrain-like organoids.
Journal
NPJ Parkinson's disease
ISSN: 2373-8057
Titre abrégé: NPJ Parkinsons Dis
Pays: United States
ID NLM: 101675390
Informations de publication
Date de publication:
2019
2019
Historique:
received:
06
08
2018
accepted:
07
03
2019
entrez:
10
4
2019
pubmed:
10
4
2019
medline:
10
4
2019
Statut:
epublish
Résumé
Modeling Parkinson's disease (PD) using advanced experimental in vitro models is a powerful tool to study disease mechanisms and to elucidate unexplored aspects of this neurodegenerative disorder. Here, we demonstrate that three-dimensional (3D) differentiation of expandable midbrain floor plate neural progenitor cells (mfNPCs) leads to organoids that resemble key features of the human midbrain. These organoids are composed of midbrain dopaminergic neurons (mDANs), which produce and secrete dopamine. Midbrain-specific organoids derived from PD patients carrying the
Identifiants
pubmed: 30963107
doi: 10.1038/s41531-019-0078-4
pii: 78
pmc: PMC6450999
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5Déclaration de conflit d'intérêts
The authors declare no competing interests.
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