Hemostatic assessment of combined anticoagulant therapy using warfarin and prothrombin complex concentrates in a case of severe protein C deficiency.


Journal

International journal of hematology
ISSN: 1865-3774
Titre abrégé: Int J Hematol
Pays: Japan
ID NLM: 9111627

Informations de publication

Date de publication:
Jun 2019
Historique:
received: 05 01 2019
accepted: 02 04 2019
revised: 01 04 2019
pubmed: 10 4 2019
medline: 15 11 2019
entrez: 10 4 2019
Statut: ppublish

Résumé

Patients with severe congenital protein (P)C deficiency require long-term anticoagulant management. Recombinant PC concentrates for prophylactic use are not available in Japan; prothrombin complex concentrates (PCC), containing factors (F)II, VII, IX, X, and PC (PPSB-HT

Identifiants

pubmed: 30963470
doi: 10.1007/s12185-019-02645-7
pii: 10.1007/s12185-019-02645-7
doi:

Substances chimiques

Anticoagulants 0
Blood Coagulation Factors 0
prothrombin complex concentrates 37224-63-8
Warfarin 5Q7ZVV76EI
VKORC1 protein, human EC 1.17.4.4
Vitamin K Epoxide Reductases EC 1.17.4.4

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

650-656

Subventions

Organisme : Ministry of Education, Culture, Sports, Science and Technology (JP)
ID : 18K07885
Organisme : Japan Agency for Medical Research and Development
ID : 18ek0109210h0002

Références

Thromb Res. 2002 Oct 1;108(1):25-30
pubmed: 12586128
Blood. 2003 Sep 1;102(5):1686-92
pubmed: 12730108
Haemophilia. 2008 Nov;14(6):1214-21
pubmed: 19141162
Thromb Res. 2009 May;124(1):137-43
pubmed: 19157524
Blood. 2010 Aug 12;116(6):878-85
pubmed: 20400681
Chest. 2012 Feb;141(2 Suppl):e737S-e801S
pubmed: 22315277
Haemophilia. 2013 May;19(3):378-84
pubmed: 23379934
Int J Lab Hematol. 2016 May;38 Suppl 1:4-11
pubmed: 27161771
Int J Hematol. 2017 Jan;105(1):52-58
pubmed: 27539155
Rinsho Ketsueki. 1986 Oct;27(10):1971-6
pubmed: 3820617
J Biol Chem. 1994 Jul 22;269(29):18735-8
pubmed: 8034625

Auteurs

Kenichi Ogiwara (K)

Department of Pediatrics, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

Keiji Nogami (K)

Department of Pediatrics, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan. roc-noga@naramed-u.ac.jp.

Kuniyoshi Mizumachi (K)

Department of Pediatrics, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

Takashi Nakagawa (T)

Department of Pediatrics, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

Nozomi Noda (N)

Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital, Fukuoka, Japan.

Shouichi Ohga (S)

Department of Pediatrics, Kyushu University Hospital, Fukuoka, Japan.

Midori Shima (M)

Department of Pediatrics, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

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Classifications MeSH