Transcriptional down-regulation of
Adult
Aged
CD4-Positive T-Lymphocytes
/ chemistry
Cells, Cultured
Disease Resistance
Down-Regulation
Family
Female
HIV Infections
/ immunology
HIV Long-Term Survivors
HIV-1
/ growth & development
Humans
Macrophages
/ chemistry
Male
Middle Aged
Receptors, CCR2
/ biosynthesis
Receptors, CCR5
/ biosynthesis
Viral Tropism
Young Adult
HIV
ccr2
ccr5
elite controllers
human
infectious disease
microbiology
transcription
viremic controllers
virus
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
09 04 2019
09 04 2019
Historique:
received:
12
12
2018
accepted:
01
04
2019
entrez:
10
4
2019
pubmed:
10
4
2019
medline:
27
2
2020
Statut:
epublish
Résumé
HIV +Elite and Viremic controllers (EC/VCs) are able to control virus infection, perhaps because of host genetic determinants. We identified 16% (21 of 131) EC/VCs with CD4 +T cells with resistance specific to R5-tropic HIV, reversed after introduction of
Identifiants
pubmed: 30964004
doi: 10.7554/eLife.44360
pii: 44360
pmc: PMC6456299
doi:
pii:
Substances chimiques
CCR2 protein, human
0
CCR5 protein, human
0
Receptors, CCR2
0
Receptors, CCR5
0
Banques de données
GEO
['GSE122321', 'GSE122322', 'GSE122323']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : P30 AI050409
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIH HHS
ID : S10 OD018521
Pays : United States
Organisme : NIH HHS
ID : P30AI050409
Pays : United States
Organisme : NIDA NIH HHS
ID : DP1DA036463
Pays : United States
Déclaration de conflit d'intérêts
EG, PR, UI, RL, SM, AC, JP, TL, VM, DR, BW, SD, RS No competing interests declared
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