Cellular Senescence: The Trojan Horse in Chronic Lung Diseases.
chronic obstructive pulmonary disease
idiopathic pulmonary fibrosis
lung
senescence
senescence-associated secretory phenotype
Journal
American journal of respiratory cell and molecular biology
ISSN: 1535-4989
Titre abrégé: Am J Respir Cell Mol Biol
Pays: United States
ID NLM: 8917225
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
pubmed:
10
4
2019
medline:
13
2
2020
entrez:
10
4
2019
Statut:
ppublish
Résumé
Senescence is a cell fate decision characterized by irreversible arrest of proliferation accompanied by a senescence-associated secretory phenotype. Traditionally, cellular senescence has been recognized as a beneficial physiological mechanism during development and wound healing and in tumor suppression. However, in recent years, evidence of negative consequences of cellular senescence has emerged, illuminating its role in several chronic pathologies. In this context, senescent cells persist or accumulate and have detrimental consequences. In this review, we discuss the possibility that in chronic obstructive pulmonary disease, persistent senescence impairs wound healing in the lung caused by secretion of proinflammatory senescence-associated secretory phenotype factors and exhaustion of progenitor cells. In contrast, in idiopathic pulmonary fibrosis, chronic senescence in alveolar epithelial cells exacerbates the accumulation of senescent fibroblasts together with production of extracellular matrix. We review how cellular senescence may contribute to lung disease pathology.
Identifiants
pubmed: 30965013
doi: 10.1165/rcmb.2018-0410TR
pmc: PMC6604222
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
21-30Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL135062
Pays : United States
Organisme : NIA NIH HHS
ID : R00 AG049126
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL113105
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL123766
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL131789
Pays : United States
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