Lymphopenic community-acquired pneumonia is associated with a dysregulated immune response and increased severity and mortality.
Aged
Aged, 80 and over
Community-Acquired Infections
/ complications
Cytokines
/ blood
Female
Hospitalization
/ statistics & numerical data
Humans
Immunocompetence
Immunoglobulin G
/ blood
Lymphocyte Subsets
/ immunology
Lymphopenia
/ complications
Male
Middle Aged
Pneumonia
/ immunology
Prognosis
Prospective Studies
Severity of Illness Index
Spain
Adaptive immunity
Host response
Pneumonia
Journal
The Journal of infection
ISSN: 1532-2742
Titre abrégé: J Infect
Pays: England
ID NLM: 7908424
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
24
10
2018
revised:
20
02
2019
accepted:
02
04
2019
pubmed:
10
4
2019
medline:
16
7
2020
entrez:
10
4
2019
Statut:
ppublish
Résumé
Lymphopenic (<724 lymphocytes/µL) community-acquired pneumonia (L-CAP) is an immunophenotype with an increased risk of mortality. We aimed to characterize the l-CAP immunophenotype though lymphocyte subsets and the inflammatory response and its relationship with severity at presentation and outcome. Prospective study of 217 immunocompetent patients hospitalized for CAP. Lymphocyte subsets (CD4 39% of patients showed l-CAP, with decreased levels of all lymphocyte subsets with a partial recovery of CD4 l-CAP is characterized by CD4
Identifiants
pubmed: 30965065
pii: S0163-4453(19)30118-5
doi: 10.1016/j.jinf.2019.04.006
pii:
doi:
Substances chimiques
Cytokines
0
Immunoglobulin G
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
423-431Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.