Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study.

Aged Alzheimer Disease / cerebrospinal fluid Amyloid beta-Peptides / cerebrospinal fluid Apolipoproteins E / genetics Biomarkers / cerebrospinal fluid Chitinase-3-Like Protein 1 Cognitive Dysfunction / cerebrospinal fluid Female Humans Longitudinal Studies Male Middle Aged Neurofilament Proteins / cerebrospinal fluid Peptide Fragments Phosphorylation tau Proteins / cerebrospinal fluid

Alzheimer Amyloid CSF Inflammation Neurofilaments Tau YKL-40

Journal

Alzheimer's & dementia : the journal of the Alzheimer's Association

ISSN: 1552-5279

Titre abrégé: Alzheimers Dement

Pays: United States

ID NLM: 101231978

Informations de publication

Date de publication:
06 2019

Historique:

received: 27 08 2018

revised: 29 11 2018

accepted: 21 01 2019

pubmed: 11 4 2019

medline: 23 6 2020

entrez: 11 4 2019

Statut: ppublish

Résumé

Within-person trajectories of cerebrospinal fluid (CSF) biomarkers in Alzheimer's disease (AD) are not well defined. We included 467 subjects from the BIOMARKAPD study with at least two serial CSF samples. Diagnoses were subjective cognitive decline (n = 75), mild cognitive impairment (n = 128), and AD dementia (n = 110), and a group of cognitively unimpaired subjects (n = 154) were also included. We measured baseline and follow-up CSF levels of total tau (t-tau), phosphorylated tau (p-tau), YKL-40, and neurofilament light (NfL). Median CSF sampling interval was 2.1 years. CSF levels of t-tau, p-tau, NfL, and YKL-40 were 2% higher per each year of baseline age in controls (P <.001). In AD, t-tau levels were 1% lower (P <.001) and p-tau levels did not change per each year of baseline age. Longitudinally, only NfL (P <.001) and YKL-40 (P <.02) increased during the study period. All four CSF biomarkers increase with age, but this effect deviates in AD for t-tau and p-tau.

Identifiants

DOI: 10.1016/j.jalz.2019.01.015 PMID: 30967340

pubmed: 30967340

pii: S1552-5260(19)30047-0

doi: 10.1016/j.jalz.2019.01.015

pii:

doi:

Substances chimiques

Amyloid beta-Peptides 0

Apolipoproteins E 0

Biomarkers 0

CHI3L1 protein, human 0

Chitinase-3-Like Protein 1 0

Neurofilament Proteins 0

Peptide Fragments 0

amyloid beta-protein (1-42) 0

tau Proteins 0

Types de publication

Journal Article Multicenter Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

742-753