Proteomic evidence of specific IGKV1-8 association with cystic lung light chain deposition disease.
Journal
Blood
ISSN: 1528-0020
Titre abrégé: Blood
Pays: United States
ID NLM: 7603509
Informations de publication
Date de publication:
27 06 2019
27 06 2019
Historique:
received:
22
01
2019
accepted:
19
03
2019
pubmed:
11
4
2019
medline:
10
1
2020
entrez:
11
4
2019
Statut:
ppublish
Résumé
We previously reported a new form of light chain deposition disease (LCDD) presenting as diffuse cystic lung disorder that differs from the usual systemic form with respect to patient age, the male/female ratio, the involved organs, and the hematologic characteristics. We also demonstrated that the light chains were produced by an intrapulmonary B-cell clone and that this clone shared a stereotyped antigen receptor IGHV4-34/IGKV1. However, we only analyzed 3 patients. We conducted a retrospective study including lung tissue samples from 24 patients with pulmonary LCDD (
Identifiants
pubmed: 30967366
pii: S0006-4971(20)42453-X
doi: 10.1182/blood.2019898577
doi:
Substances chimiques
Immunoglobulin Light Chains
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2741-2744Informations de copyright
© 2019 by The American Society of Hematology.