Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D.
KCNQ1
arrhythmia
computational biology
gain-of-function
long QT syndrome
sinus node
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2019
2019
Historique:
received:
18
12
2018
accepted:
28
02
2019
entrez:
11
4
2019
pubmed:
11
4
2019
medline:
11
4
2019
Statut:
epublish
Résumé
The congenital long QT syndrome (LQTS) is a cardiac electrophysiological disorder that can cause sudden cardiac death. LQT1 is a subtype of LQTS caused by mutations in KCNQ1, affecting the slow delayed-rectifier potassium current (
Identifiants
pubmed: 30967788
doi: 10.3389/fphys.2019.00259
pmc: PMC6430739
doi:
Types de publication
Journal Article
Langues
eng
Pagination
259Subventions
Organisme : Medical Research Council
ID : MR/M017354/1
Pays : United Kingdom
Organisme : National Centre for the Replacement, Refinement and Reduction of Animals in Research
ID : NC/K000225/1
Pays : United Kingdom
Organisme : National Centre for the Replacement, Refinement and Reduction of Animals in Research
ID : NC/P001076/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/16/30/32162
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/17/22/32644
Pays : United Kingdom
Organisme : British Heart Foundation
ID : SP/15/9/31605
Pays : United Kingdom
Organisme : National Centre for the Replacement, Refinement and Reduction of Animals in Research
ID : NC/C013105/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/14/59/31000
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : National Centre for the Replacement, Refinement and Reduction of Animals in Research
ID : NC/C013202/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/12/21/29482
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/12/59/29756
Pays : United Kingdom
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