Accumbal Dopamine Release Tracks the Expectation of Dopamine Neuron-Mediated Reinforcement.
dopamine
intracranial self-stimulation
nucleus accumbens
optogenetics
ventral tegmental area
voltammetry
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
09 04 2019
09 04 2019
Historique:
received:
24
08
2018
revised:
02
11
2018
accepted:
13
03
2019
entrez:
11
4
2019
pubmed:
11
4
2019
medline:
23
6
2020
Statut:
ppublish
Résumé
Dopamine (DA) transmission in the nucleus accumbens (NAc) facilitates cue-reward associations and appetitive action. Reward-related accumbal DA release dynamics are traditionally ascribed to ventral tegmental area (VTA) DA neurons. Activation of VTA to NAc DA signaling is thought to reinforce action and transfer reward-related information to predictive cues, allowing cues to guide behavior and elicit dopaminergic activity. Here, we use optogenetics to control DA neuron activity and voltammetry to simultaneously record accumbal DA release in order to quantify how reinforcer-evoked dopaminergic activity shapes conditioned mesolimbic DA transmission. We find that cues predicting access to DA neuron self-stimulation elicit conditioned responding and NAc DA release. However, cue-evoked DA release does not reflect the cost or magnitude of DA neuron activation. Accordingly, conditioned accumbal DA release selectively tracks the expected availability of DA-neuron-mediated reinforcement. This work provides insight into how mesolimbic DA transmission drives and encodes appetitive action.
Identifiants
pubmed: 30970251
pii: S2211-1247(19)30385-7
doi: 10.1016/j.celrep.2019.03.055
pmc: PMC6481661
mid: NIHMS1526703
pii:
doi:
Substances chimiques
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
481-490.e3Subventions
Organisme : NIDA NIH HHS
ID : F32 DA041827
Pays : United States
Organisme : NIDA NIH HHS
ID : K99 DA047432
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA022340
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA045639
Pays : United States
Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
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