Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality.

Aged Arachidonic Acid / blood Biomarkers / blood Cardiovascular Diseases / blood Diet, Healthy Dietary Fats / administration & dosage Female Humans Linoleic Acid / administration & dosage Male Middle Aged Nutritive Value Observational Studies as Topic Primary Prevention / methods Protective Factors Recommended Dietary Allowances Risk Assessment Risk Factors Risk Reduction Behavior
arachidonic acid biomarkers cardiovascular diseases diet epidemiology linoleic acid primary prevention

Journal

Circulation
ISSN: 1524-4539
Titre abrégé: Circulation
Pays: United States
ID NLM: 0147763

Informations de publication

Date de publication:
21 05 2019
Historique:
pubmed: 12 4 2019
medline: 3 3 2020
entrez: 12 4 2019
Statut: ppublish

Résumé

Global dietary recommendations for and cardiovascular effects of linoleic acid, the major dietary omega-6 fatty acid, and its major metabolite, arachidonic acid, remain controversial. To address this uncertainty and inform international recommendations, we evaluated how in vivo circulating and tissue levels of linoleic acid (LA) and arachidonic acid (AA) relate to incident cardiovascular disease (CVD) across multiple international studies. We performed harmonized, de novo, individual-level analyses in a global consortium of 30 prospective observational studies from 13 countries. Multivariable-adjusted associations of circulating and adipose tissue LA and AA biomarkers with incident total CVD and subtypes (coronary heart disease, ischemic stroke, cardiovascular mortality) were investigated according to a prespecified analytic plan. Levels of LA and AA, measured as the percentage of total fatty acids, were evaluated linearly according to their interquintile range (ie, the range between the midpoint of the first and fifth quintiles), and categorically by quintiles. Study-specific results were pooled using inverse-variance-weighted meta-analysis. Heterogeneity was explored by age, sex, race, diabetes mellitus, statin use, aspirin use, omega-3 levels, and fatty acid desaturase 1 genotype (when available). In 30 prospective studies with medians of follow-up ranging 2.5 to 31.9 years, 15 198 incident cardiovascular events occurred among 68 659 participants. Higher levels of LA were significantly associated with lower risks of total CVD, cardiovascular mortality, and ischemic stroke, with hazard ratios per interquintile range of 0.93 (95% CI, 0.88-0.99), 0.78 (0.70-0.85), and 0.88 (0.79-0.98), respectively, and nonsignificantly with lower coronary heart disease risk (0.94; 0.88-1.00). Relationships were similar for LA evaluated across quintiles. AA levels were not associated with higher risk of cardiovascular outcomes; in a comparison of extreme quintiles, higher levels were associated with lower risk of total CVD (0.92; 0.86-0.99). No consistent heterogeneity by population subgroups was identified in the observed relationships. In pooled global analyses, higher in vivo circulating and tissue levels of LA and possibly AA were associated with lower risk of major cardiovascular events. These results support a favorable role for LA in CVD prevention.

Sections du résumé

BACKGROUND
Global dietary recommendations for and cardiovascular effects of linoleic acid, the major dietary omega-6 fatty acid, and its major metabolite, arachidonic acid, remain controversial. To address this uncertainty and inform international recommendations, we evaluated how in vivo circulating and tissue levels of linoleic acid (LA) and arachidonic acid (AA) relate to incident cardiovascular disease (CVD) across multiple international studies.
METHODS
We performed harmonized, de novo, individual-level analyses in a global consortium of 30 prospective observational studies from 13 countries. Multivariable-adjusted associations of circulating and adipose tissue LA and AA biomarkers with incident total CVD and subtypes (coronary heart disease, ischemic stroke, cardiovascular mortality) were investigated according to a prespecified analytic plan. Levels of LA and AA, measured as the percentage of total fatty acids, were evaluated linearly according to their interquintile range (ie, the range between the midpoint of the first and fifth quintiles), and categorically by quintiles. Study-specific results were pooled using inverse-variance-weighted meta-analysis. Heterogeneity was explored by age, sex, race, diabetes mellitus, statin use, aspirin use, omega-3 levels, and fatty acid desaturase 1 genotype (when available).
RESULTS
In 30 prospective studies with medians of follow-up ranging 2.5 to 31.9 years, 15 198 incident cardiovascular events occurred among 68 659 participants. Higher levels of LA were significantly associated with lower risks of total CVD, cardiovascular mortality, and ischemic stroke, with hazard ratios per interquintile range of 0.93 (95% CI, 0.88-0.99), 0.78 (0.70-0.85), and 0.88 (0.79-0.98), respectively, and nonsignificantly with lower coronary heart disease risk (0.94; 0.88-1.00). Relationships were similar for LA evaluated across quintiles. AA levels were not associated with higher risk of cardiovascular outcomes; in a comparison of extreme quintiles, higher levels were associated with lower risk of total CVD (0.92; 0.86-0.99). No consistent heterogeneity by population subgroups was identified in the observed relationships.
CONCLUSIONS
In pooled global analyses, higher in vivo circulating and tissue levels of LA and possibly AA were associated with lower risk of major cardiovascular events. These results support a favorable role for LA in CVD prevention.

Identifiants

DOI: 10.1161/CIRCULATIONAHA.118.038908 PMID: 30971107 PMC: PMC6582360
pubmed: 30971107
doi: 10.1161/CIRCULATIONAHA.118.038908
pmc: PMC6582360
mid: NIHMS1527419
doi:

Substances chimiques

Biomarkers 0
Dietary Fats 0
Arachidonic Acid 27YG812J1I
Linoleic Acid 9KJL21T0QJ

Types de publication

Journal Article Meta-Analysis Multicenter Study Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2422-2436

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL034594
Pays : United States
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Commentaires et corrections

Type : CommentIn

Références

Nat Genet. 2012 Sep;44(9):991-1005
pubmed: 22885924
PLoS One. 2012;7(7):e41681
pubmed: 22911844
Hypertension. 2008 Aug;52(2):408-14
pubmed: 18606902
Circulation. 2014 Oct 7;130(15):1245-53
pubmed: 25124495
Prog Lipid Res. 2008 Sep;47(5):348-80
pubmed: 18435934
Biochimie. 2009 Jun;91(6):791-5
pubmed: 19455748
Nutr Metab Cardiovasc Dis. 2013 Aug;23(8):737-43
pubmed: 22633188
Am J Clin Nutr. 2012 May;95(5):1003-12
pubmed: 22492369
Cancer Epidemiol Biomarkers Prev. 2010 Apr;19(4):938-46
pubmed: 20332276
Circulation. 2009 Feb 17;119(6):902-7
pubmed: 19171857
Am J Clin Nutr. 1994 Dec;60(6 Suppl):1017S-1022S
pubmed: 7977143
World Rev Nutr Diet. 2011;102:137-143
pubmed: 21865827
Ann Nutr Metab. 1999;43(2):127-30
pubmed: 10436312
Stroke. 1995 May;26(5):778-82
pubmed: 7740566
Lancet Diabetes Endocrinol. 2017 Dec;5(12):965-974
pubmed: 29032079
Nat Genet. 2009 Jan;41(1):56-65
pubmed: 19060906
J Nutr. 2006 Mar;136(3):565-9
pubmed: 16484525
BMJ. 2016 Apr 12;353:i1246
pubmed: 27071971
Am J Clin Nutr. 2018 Sep 1;108(3):594-602
pubmed: 30084912
PLoS Med. 2016 Jul 19;13(7):e1002087
pubmed: 27434027
JAMA Intern Med. 2016 Aug 1;176(8):1155-66
pubmed: 27357102
Atherosclerosis. 2007 Jul;193(1):1-10
pubmed: 17507020
J Nutr. 2017 Nov;147(11):2118-2125
pubmed: 28931585
Ann Intern Med. 2014 Mar 18;160(6):398-406
pubmed: 24723079
J Nutr. 2014 Jan;144(1):33-41
pubmed: 24225449
Nat Genet. 2013 Nov;45(11):1274-1283
pubmed: 24097068
Nat Genet. 2013 Jun;45(6):621-31
pubmed: 23583979
JAMA Cardiol. 2016 Oct 1;1(7):745-753
pubmed: 27541681
Prostaglandins Leukot Essent Fatty Acids. 2018 Oct;137:26-38
pubmed: 30293594
J Acad Nutr Diet. 2014 Jan;114(1):136-53
pubmed: 24342605
Circulation. 2014 Oct 28;130(18):1568-78
pubmed: 25161045
Psychol Methods. 2006 Jun;11(2):193-206
pubmed: 16784338
Am J Epidemiol. 2012 Jan 1;175(1):66-73
pubmed: 22135359
World Rev Nutr Diet. 2003;92:109-32
pubmed: 14579687
Circ Cardiovasc Genet. 2014 Jun;7(3):321-331
pubmed: 24823311
Circulation. 2017 Jul 18;136(3):e1-e23
pubmed: 28620111
J Lipid Res. 2005 Feb;46(2):269-80
pubmed: 15576848
PLoS Med. 2010 Mar 23;7(3):e1000252
pubmed: 20351774
Cerebrovasc Dis. 2013;36(1):38-46
pubmed: 23920478
Am J Clin Nutr. 1994 Feb;59(2):364-70
pubmed: 8310986
Curr Opin Lipidol. 2006 Feb;17(1):22-7
pubmed: 16407712
BMJ. 2013 Feb 04;346:e8707
pubmed: 23386268
Diabetes. 2014 Jul;63(7):2356-68
pubmed: 24550191
Br J Pharmacol. 2019 Apr;176(8):1038-1050
pubmed: 29468666
Stroke. 2006 Dec;37(12):2898-903
pubmed: 17053177

Auteurs

Matti Marklund (M)

Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Sweden (M.M., U.R.).
The George Institute for Global Health and the Faculty of Medicine, University of New South Wales, Sydney, Australia (M.M., J.H.Y.W., M. Woodward).

Jason H Y Wu (JHY)

The George Institute for Global Health and the Faculty of Medicine, University of New South Wales, Sydney, Australia (M.M., J.H.Y.W., M. Woodward).

Fumiaki Imamura (F)

Medical Research Council Epidemiology Unit, University of Cambridge, United Kingdom (F.I., N.G.F., N.W.).

Liana C Del Gobbo (LC)

Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, CA (L.C.D.G.).

Amanda Fretts (A)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle (A.F., R.N.L.).

Janette de Goede (J)

Division of Human Nutrition, Wageningen University, The Netherlands (J.d.G., J.M. Geleijnse).

Peilin Shi (P)

Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (P.S., N.E.-A., P.F.J., R.M., D.M.).

Nathan Tintle (N)

Department of Mathematics and Statistics, Dordt College, Sioux Centre, IA (N.T., A.K., J. Veenstra).

Maria Wennberg (M)

Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Sweden (M. Wennberg).

Stella Aslibekyan (S)

Department of Epidemiology, University of Alabama at Birmingham (S.A.).

Tzu-An Chen (TA)

USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX (T.-A.C., A.C.W.).

Marcia C de Oliveira Otto (MC)

Division of Epidemiology, Human Genetics and Environmental Sciences, the University of Texas Health Science Center, School of Public Health, Houston (M.C.d.O.O.).

Yoichiro Hirakawa (Y)

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (Y.H.).

Helle Højmark Eriksen (HH)

Unit of Epidemiology and Biostatistics, Aalborg University Hospital, Denmark (H.H.E.).

Janine Kröger (J)

Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany (J.K., M.B.S.).

Federica Laguzzi (F)

Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (F.L., U.d.F., B.G., K.L.).

Maria Lankinen (M)

Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio (N. Lankinen, J. Virtanen, J.M., M.I.J.U.).

Rachel A Murphy (RA)

University of British Columbia, Vancouver, British Columbia, Canada (R.A.M.).

Kiesha Prem (K)

Saw Swee Hock School of Public Health, National University of Singapore (K.P., W.-P.K., R.M.v.D.).

Cécilia Samieri (C)

Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, TUMR 1219, France (C.S., C.H.).

Jyrki Virtanen (J)

Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio (N. Lankinen, J. Virtanen, J.M., M.I.J.U.).

Alexis C Wood (AC)

USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX (T.-A.C., A.C.W.).

Kerry Wong (K)

Centre for Epidemiology and Biostatistics, The University of Melbourne, Australia (K.W., G.G., A.H.).

Wei-Sin Yang (WS)

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei (W.-S.Y., K.-L.C.).

Xia Zhou (X)

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (X.Z., L.S.).

Ana Baylin (A)

Departments of Nutritional Sciences and Epidemiology, School of Public Health, University of Michigan, Ann Arbor (A.B.).

Jolanda M A Boer (JMA)

Centre for Nutrition, Prevention and Health Services, National Institute of Public Health and the Environment, Bilthoven, The Netherlands (J.M.A.B., W.M.M.V.).

Ingeborg A Brouwer (IA)

Health Sciences, Vrije Universiteit, Amsterdam, The Netherlands (I.A.B.).

Hannia Campos (H)

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (H.C., F.B.H., E.R., Q.S., W.W.).

Paulo H M Chaves (PHM)

Benjamin Leon for Geriatrics Research and Education, Herbert Wertheim College of Medicine, Florida International University, Miami (P.H.M.C.).

Kuo-Liong Chien (KL)

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei (W.-S.Y., K.-L.C.).
Department of Internal Medicine, National Taiwan University Hospital, Taipei (K.-L.C., H.-J.L.).

Ulf de Faire (U)

Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (F.L., U.d.F., B.G., K.L.).

Luc Djoussé (L)

Brigham and Women's Hospital, Boston Veterans Affairs Healthcare System, MA (L.D., J.M. Gaziano).

Gudny Eiriksdottir (G)

Icelandic Heart Association, Kópavogur, Iceland; and Faculty of Medicine, University of Iceland, Reykjavik (G.E., V.G., A.V.S.).

Naglaa El-Abbadi (N)

Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (P.S., N.E.-A., P.F.J., R.M., D.M.).
USDA Jean Mayer Human Nutrition Research Center, Boston, MA (N.E.-A., P.F.J.).

Nita G Forouhi (NG)

Medical Research Council Epidemiology Unit, University of Cambridge, United Kingdom (F.I., N.G.F., N.W.).

J Michael Gaziano (J)

Brigham and Women's Hospital, Boston Veterans Affairs Healthcare System, MA (L.D., J.M. Gaziano).

Johanna M Geleijnse (JM)

Division of Human Nutrition, Wageningen University, The Netherlands (J.d.G., J.M. Geleijnse).

Bruna Gigante (B)

Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (F.L., U.d.F., B.G., K.L.).

Graham Giles (G)

Centre for Epidemiology and Biostatistics, The University of Melbourne, Australia (K.W., G.G., A.H.).

Eliseo Guallar (E)

Division of Environmental Epidemiology, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.).

Vilmundur Gudnason (V)

Icelandic Heart Association, Kópavogur, Iceland; and Faculty of Medicine, University of Iceland, Reykjavik (G.E., V.G., A.V.S.).

Tamara Harris (T)

National Institute on Aging, Bethesda, MD (T.H.).

William S Harris (WS)

Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls (W.S.H.).
OmegaQuant Analytics, LLC, Sioux Falls, SD (W.S.H.).

Catherine Helmer (C)

Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, TUMR 1219, France (C.S., C.H.).

Mai-Lis Hellenius (ML)

Department of Medicine, Cardiology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden (M.-L.H.).

Allison Hodge (A)

Centre for Epidemiology and Biostatistics, The University of Melbourne, Australia (K.W., G.G., A.H.).

Frank B Hu (FB)

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (H.C., F.B.H., E.R., Q.S., W.W.).
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (F.B.H., E.R., W.W.).
Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (F.B.H., E.R., Q.S., W.W.).

Paul F Jacques (PF)

Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (P.S., N.E.-A., P.F.J., R.M., D.M.).
USDA Jean Mayer Human Nutrition Research Center, Boston, MA (N.E.-A., P.F.J.).

Jan-Håkan Jansson (JH)

Department of Public Health and Clinical Medicine, Research Unit Skellefteå, Umeå University, Umeå, Sweden (J.-H.J.).

Anya Kalsbeek (A)

Department of Mathematics and Statistics, Dordt College, Sioux Centre, IA (N.T., A.K., J. Veenstra).

Kay-Tee Khaw (KT)

Department of Public Health and Primary Care, University of Cambridge School of Clinical Medicine, United Kingdom (K.-T.K., R.L.).

Woon-Puay Koh (WP)

Saw Swee Hock School of Public Health, National University of Singapore (K.P., W.-P.K., R.M.v.D.).
Duke-NUS Medical School, Singapore (W.-P.K.).

Markku Laakso (M)

Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland (M. Laakso).

Karin Leander (K)

Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (F.L., U.d.F., B.G., K.L.).

Hung-Ju Lin (HJ)

Department of Internal Medicine, National Taiwan University Hospital, Taipei (K.-L.C., H.-J.L.).

Lars Lind (L)

Department of Medical Sciences, Uppsala University, Sweden (L.L., J.S.).

Robert Luben (R)

Department of Public Health and Primary Care, University of Cambridge School of Clinical Medicine, United Kingdom (K.-T.K., R.L.).

Juhua Luo (J)

Department of Epidemiology and Biostatistics, Indiana University, Bloomington (J.L.).

Barbara McKnight (B)

Department of Biostatistics, School of Public Health, University of Washington, Seattle (B.M.).

Jaakko Mursu (J)

Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio (N. Lankinen, J. Virtanen, J.M., M.I.J.U.).

Toshiharu Ninomiya (T)

Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T.N.).

Kim Overvad (K)

Department of Public Health, Section for Epidemiology, Aarhus University, Denmark (K.O.).
Department of Cardiology, Aalborg University Hospital, Denmark (K.O., M.S.N.).

Bruce M Psaty (BM)

Cardiovascular Health Study, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle (B.M.P.).
Kaiser Permanente Washington Health Research Institute, Seattle (B.M.P.).

Eric Rimm (E)

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (H.C., F.B.H., E.R., Q.S., W.W.).
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (F.B.H., E.R., W.W.).
Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (F.B.H., E.R., Q.S., W.W.).

Matthias B Schulze (MB)

Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany (J.K., M.B.S.).

David Siscovick (D)

The New York Academy of Medicine (D.S.).

Michael Skjelbo Nielsen (M)

Department of Cardiology, Aalborg University Hospital, Denmark (K.O., M.S.N.).

Albert V Smith (AV)

Icelandic Heart Association, Kópavogur, Iceland; and Faculty of Medicine, University of Iceland, Reykjavik (G.E., V.G., A.V.S.).

Brian T Steffen (BT)

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis (B.T.S., M.Y.T.).

Lyn Steffen (L)

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (X.Z., L.S.).

Qi Sun (Q)

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (H.C., F.B.H., E.R., Q.S., W.W.).
Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (F.B.H., E.R., Q.S., W.W.).

Johan Sundström (J)

Department of Medical Sciences, Uppsala University, Sweden (L.L., J.S.).

Michael Y Tsai (MY)

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis (B.T.S., M.Y.T.).

Hugh Tunstall-Pedoe (H)

Cardiovascular Epidemiology Unit, Institute of Cardiovascular Research, University of Dundee, United Kingdom (H.T.-P., M. Woodward).

Matti I J Uusitupa (MIJ)

Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio (N. Lankinen, J. Virtanen, J.M., M.I.J.U.).

Rob M van Dam (RM)

Saw Swee Hock School of Public Health, National University of Singapore (K.P., W.-P.K., R.M.v.D.).

Jenna Veenstra (J)

Department of Mathematics and Statistics, Dordt College, Sioux Centre, IA (N.T., A.K., J. Veenstra).

W M Monique Verschuren (WM)

Centre for Nutrition, Prevention and Health Services, National Institute of Public Health and the Environment, Bilthoven, The Netherlands (J.M.A.B., W.M.M.V.).
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands (W.M.M.V.).

Nick Wareham (N)

Medical Research Council Epidemiology Unit, University of Cambridge, United Kingdom (F.I., N.G.F., N.W.).

Walter Willett (W)

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (H.C., F.B.H., E.R., Q.S., W.W.).
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (F.B.H., E.R., W.W.).
Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (F.B.H., E.R., Q.S., W.W.).

Mark Woodward (M)

The George Institute for Global Health and the Faculty of Medicine, University of New South Wales, Sydney, Australia (M.M., J.H.Y.W., M. Woodward).
Cardiovascular Epidemiology Unit, Institute of Cardiovascular Research, University of Dundee, United Kingdom (H.T.-P., M. Woodward).
The George Institute for Global Health, University of Oxford, United Kingdom (M. Woodward).

Jian-Min Yuan (JM)

Division of Cancer Control and Population Sciences, UPMC Hillman Cancer, and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA (J.-M.Y.).

Renata Micha (R)

Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (P.S., N.E.-A., P.F.J., R.M., D.M.).

Rozenn N Lemaitre (RN)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle (A.F., R.N.L.).

Dariush Mozaffarian (D)

Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (P.S., N.E.-A., P.F.J., R.M., D.M.).

Ulf Risérus (U)

Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Sweden (M.M., U.R.).

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Biomarkers of Dietary Omega-6 Fatty Acids and...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras indispensables › Acides arachidoniques › Acide arachidonique › Biomarkers of Dietary Omega-6 Fatty Acids and...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Biomarkers of Dietary Omega-6 Fatty Acids and...
questionsmedicales.fr › Maladies cardiovasculaires › Biomarkers of Dietary Omega-6 Fatty Acids and...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Régime alimentaire sain › Biomarkers of Dietary Omega-6 Fatty Acids and...
questionsmedicales.fr › Aliments et boissons › Aliments › Matières grasses alimentaires › Biomarkers of Dietary Omega-6 Fatty Acids and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Biomarkers of Dietary Omega-6 Fatty Acids and...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras omega-6 › Acides linoléiques › Acide linoléique › Biomarkers of Dietary Omega-6 Fatty Acids and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Biomarkers of Dietary Omega-6 Fatty Acids and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Qualité alimentaire › Valeur nutritive › Biomarkers of Dietary Omega-6 Fatty Acids and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Études observationnelles comme sujet › Biomarkers of Dietary Omega-6 Fatty Acids and...
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questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Biomarkers of Dietary Omega-6 Fatty Acids and...
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