Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription.

Amino Acid Motifs Animals Drosophila Proteins / chemistry Drosophila melanogaster Phosphorylation Protein Tyrosine Phosphatases / chemistry RNA Polymerase II / chemistry
CTD code DNA transcription RNA polymerase II X-ray crystallography intrinsically disordered protein mass spectrometry (MS) phosphatase phosphoryl motif proline isomerization tyrosine phosphorylation

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
24 05 2019
Historique:
received: 25 01 2019
revised: 03 04 2019
pubmed: 12 4 2019
medline: 18 12 2019
entrez: 12 4 2019
Statut: ppublish

Résumé

The C-terminal domain (CTD) of RNA polymerase II contains a repetitive heptad sequence (YSPTSPS) whose phosphorylation states coordinate eukaryotic transcription by recruiting protein regulators. The precise placement and removal of phosphate groups on specific residues of the CTD are critical for the fidelity and effectiveness of RNA polymerase II-mediated transcription. During transcriptional elongation, phosphoryl-Ser

Identifiants

DOI: 10.1074/jbc.RA119.007697 PMID: 30971428 PMC: PMC6544836
pubmed: 30971428
pii: S0021-9258(20)36346-8
doi: 10.1074/jbc.RA119.007697
pmc: PMC6544836
pii:
doi:

Substances chimiques

Drosophila Proteins 0
RNA Polymerase II EC 2.7.7.-
Protein Tyrosine Phosphatases EC 3.1.3.48
Ssu72 protein, Drosophila EC 3.1.3.48

Banques de données

PDB
['6NPW', '3P9Y', '3O2Q', '4IMI']

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

8592-8605

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM104896
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM125882
Pays : United States

Informations de copyright

© 2019 Irani et al.

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Auteurs

Seema Irani (S)

Department of Chemical Engineering, The University of Texas, Austin, Texas 78712; Department of Molecular Biosciences, The University of Texas, Austin, Texas 78712.

Sarah N Sipe (SN)

Department of Chemistry, The University of Texas, Austin, Texas 78712.

Wanjie Yang (W)

Department of Molecular Biosciences, The University of Texas, Austin, Texas 78712.

Nathaniel T Burkholder (NT)

Department of Molecular Biosciences, The University of Texas, Austin, Texas 78712.

Brian Lin (B)

Department of Molecular Biosciences, The University of Texas, Austin, Texas 78712.

Kelly Sim (K)

Department of Molecular Biosciences, The University of Texas, Austin, Texas 78712.

Wendy L Matthews (WL)

Department of Molecular Biosciences, The University of Texas, Austin, Texas 78712.

Jennifer S Brodbelt (JS)

Department of Chemistry, The University of Texas, Austin, Texas 78712.

Yan Zhang (Y)

Department of Molecular Biosciences, The University of Texas, Austin, Texas 78712; Institute for Cellular and Molecular Biology, The University of Texas, Austin, Texas 78712. Electronic address: jzhang@cm.utexas.edu.

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › Motifs d'acides aminés › Structural determinants for accurate...
questionsmedicales.fr › Eucaryotes › Animaux › Structural determinants for accurate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'arthropode › Protéines d'insecte › Protéines de Drosophila › Structural determinants for accurate...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › Structural determinants for accurate...
questionsmedicales.fr › Métabolisme › Phosphorylation › Structural determinants for accurate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein Tyrosine Phosphatases › Structural determinants for accurate...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › DNA-directed RNA polymerases › RNA polymerase II › Structural determinants for accurate...