Structural basis for auxiliary subunit KCTD16 regulation of the GABA

Binding Sites / genetics Crystallography Humans Intracellular Signaling Peptides and Proteins / chemistry Models, Molecular Nerve Tissue Proteins / chemistry Protein Binding / genetics Receptors, GABA-B / chemistry Signal Transduction / genetics
GABAB receptor KCTD crystal structure principal and auxiliary subunits

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
23 04 2019
Historique:
pubmed: 12 4 2019
medline: 26 3 2020
entrez: 12 4 2019
Statut: ppublish

Résumé

Metabotropic GABA

Identifiants

DOI: 10.1073/pnas.1903024116 PMID: 30971491 PMC: PMC6486783
pubmed: 30971491
pii: 1903024116
doi: 10.1073/pnas.1903024116
pmc: PMC6486783
doi:

Substances chimiques

Intracellular Signaling Peptides and Proteins 0
KCTD16 protein, human 0
Nerve Tissue Proteins 0
Receptors, GABA-B 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

8370-8379

Subventions

Organisme : NCRR NIH HHS
ID : S10 RR029205
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA037170
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM125801
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM124165
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA018734
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103403
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM088454
Pays : United States

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

Références

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Auteurs

Hao Zuo (H)

Department of Pharmacology, Columbia University, New York, NY 10032.
ORCID: 0000-0002-8812-7385

Ian Glaaser (I)

Department of Pharmacology, Columbia University, New York, NY 10032.
Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.

Yulin Zhao (Y)

Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.

Igor Kurinov (I)

Department of Chemistry & Chemical Biology, Cornell University, Ithaca, NY 14853.

Lidia Mosyak (L)

Department of Pharmacology, Columbia University, New York, NY 10032.

Haonan Wang (H)

Key Laboratory of Receptor Research, Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
University of Chinese Academy of Sciences, Beijing 100049, China.

Jonathan Liu (J)

Department of Pharmacology, Columbia University, New York, NY 10032.

Jinseo Park (J)

Department of Pharmacology, Columbia University, New York, NY 10032.

Aurel Frangaj (A)

Department of Pharmacology, Columbia University, New York, NY 10032.

Emmanuel Sturchler (E)

Department of Molecular Therapeutics, The Scripps Translational Science Institute, Jupiter, FL 33458.

Ming Zhou (M)

Verma and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030.

Patricia McDonald (P)

Department of Molecular Therapeutics, The Scripps Translational Science Institute, Jupiter, FL 33458.

Yong Geng (Y)

Department of Pharmacology, Columbia University, New York, NY 10032; gengyong@simm.ac.cn paul.slesinger@mssm.edu qf13@cumc.columbia.edu.
Key Laboratory of Receptor Research, Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Paul A Slesinger (PA)

Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029; gengyong@simm.ac.cn paul.slesinger@mssm.edu qf13@cumc.columbia.edu.
ORCID: 0000-0002-3868-7528

Qing R Fan (QR)

Department of Pharmacology, Columbia University, New York, NY 10032; gengyong@simm.ac.cn paul.slesinger@mssm.edu qf13@cumc.columbia.edu.
Department of Pathology & Cell Biology, Columbia University, New York, NY 10032.
ORCID: 0000-0002-9330-0963

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Structural basis for auxiliary subunit KCTD16...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Chimie physique › Cristallographie › Structural basis for auxiliary subunit KCTD16...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structural basis for auxiliary subunit KCTD16...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Structural basis for auxiliary subunit KCTD16...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Structural basis for auxiliary subunit KCTD16...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Structural basis for auxiliary subunit KCTD16...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Structural basis for auxiliary subunit KCTD16...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › Récepteurs GABA-B › Structural basis for auxiliary subunit KCTD16...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Structural basis for auxiliary subunit KCTD16...