CD105 as a tool for assessing microvessel density in renal cell carcinoma.
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
/ analysis
Carcinoma, Renal Cell
/ diagnosis
Endoglin
/ analysis
Female
Humans
Immunohistochemistry
Kidney Neoplasms
/ diagnosis
Male
Microvessels
/ pathology
Middle Aged
Neoplasm Staging
Neovascularization, Pathologic
/ diagnosis
Paraffin Embedding
Prognosis
Staining and Labeling
Angiogenesis
CD-105
endoglin
immunohistochemistry
renal cell carcinoma
Journal
Indian journal of pathology & microbiology
ISSN: 0974-5130
Titre abrégé: Indian J Pathol Microbiol
Pays: India
ID NLM: 7605904
Informations de publication
Date de publication:
Historique:
entrez:
12
4
2019
pubmed:
12
4
2019
medline:
3
8
2019
Statut:
ppublish
Résumé
Angiogenesis plays an essential role in both tumor growth and metastasis. CD105 expression was correlated with prognosis in many tumors, but its value in renal cell carcinoma (RCC) is still questionable. The aim of this study was to evaluate microvessel density (MVD) by using CD105 marker, in 95 cases of renal cell carcinoma. CD105 showed positivity in 93 cases. The mean MVD value was significantly higher in clear cell carcinoma compared to papillary and chromophobe subtypes (P = 0.000). We noticed a significant correlation between MVD and ISUP grade (P = 0.007). The highest MVD value was observed in tumors with ISUP grade 1 and 2, while the lowest MVD value was noted in ISUP grade 3 tumors. A high vessel density was identified in tumors with a low Fuhrman grade, compared to those with a high grade (P = 0.010). MVD value was lower in tumors with a larger diameter, compared to small ones (P = 0.026). In conclusion, CD105 expression (MVD) is inversely related to tumor aggressiveness in clear cell RCC and can be used as a favorable prognosis marker. The vascularity differences between histological subtypes of RCCs could be useful for a better selection of patients that may benefit from anti-angiogenic therapies.
Sections du résumé
BACKGROUND
BACKGROUND
Angiogenesis plays an essential role in both tumor growth and metastasis. CD105 expression was correlated with prognosis in many tumors, but its value in renal cell carcinoma (RCC) is still questionable.
MATERIALS AND METHODS
METHODS
The aim of this study was to evaluate microvessel density (MVD) by using CD105 marker, in 95 cases of renal cell carcinoma.
RESULTS
RESULTS
CD105 showed positivity in 93 cases. The mean MVD value was significantly higher in clear cell carcinoma compared to papillary and chromophobe subtypes (P = 0.000). We noticed a significant correlation between MVD and ISUP grade (P = 0.007). The highest MVD value was observed in tumors with ISUP grade 1 and 2, while the lowest MVD value was noted in ISUP grade 3 tumors. A high vessel density was identified in tumors with a low Fuhrman grade, compared to those with a high grade (P = 0.010). MVD value was lower in tumors with a larger diameter, compared to small ones (P = 0.026).
CONCLUSION
CONCLUSIONS
In conclusion, CD105 expression (MVD) is inversely related to tumor aggressiveness in clear cell RCC and can be used as a favorable prognosis marker. The vascularity differences between histological subtypes of RCCs could be useful for a better selection of patients that may benefit from anti-angiogenic therapies.
Identifiants
pubmed: 30971547
pii: IndianJPatholMicrobiol_2019_62_2_239_255845
doi: 10.4103/IJPM.IJPM_773_17
doi:
Substances chimiques
Biomarkers, Tumor
0
ENG protein, human
0
Endoglin
0
Types de publication
Journal Article
Langues
eng
Pagination
239-243Déclaration de conflit d'intérêts
None