p38γ is essential for cell cycle progression and liver tumorigenesis.

Aged Animals Carcinogenesis / drug effects Carcinoma, Hepatocellular / chemically induced Cell Cycle / drug effects Cell Line, Tumor Cyclin-Dependent Kinases / antagonists & inhibitors Female Hepatocytes / cytology Humans Liver / enzymology Liver Neoplasms / chemically induced Male Mice Middle Aged Mitogen-Activated Protein Kinase 12 / antagonists & inhibitors Phosphorylation Pyridones / pharmacology Retinoblastoma Protein / chemistry Sequence Homology Substrate Specificity

Journal

Nature

ISSN: 1476-4687

Titre abrégé: Nature

Pays: England

ID NLM: 0410462

Informations de publication

Date de publication:
04 2019

Historique:

received: 11 10 2017

accepted: 07 03 2019

pubmed: 12 4 2019

medline: 18 12 2019

entrez: 12 4 2019

Statut: ppublish

Résumé

The cell cycle is a tightly regulated process that is controlled by the conserved cyclin-dependent kinase (CDK)-cyclin protein complex

Identifiants

DOI: 10.1038/s41586-019-1112-8 PMID: 30971822

pubmed: 30971822

doi: 10.1038/s41586-019-1112-8

pii: 10.1038/s41586-019-1112-8

doi:

Substances chimiques

Pyridones 0

Retinoblastoma Protein 0

pirfenidone D7NLD2JX7U

Mitogen-Activated Protein Kinase 12 EC 2.7.1.-

Cyclin-Dependent Kinases EC 2.7.11.22

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

557-560

Références

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