Oncometabolites in cancer aggressiveness and tumour repopulation.
2-hydroxyglutarate
cancer
fumarate
metabolism
oncometabolites
succinate
Journal
Biological reviews of the Cambridge Philosophical Society
ISSN: 1469-185X
Titre abrégé: Biol Rev Camb Philos Soc
Pays: England
ID NLM: 0414576
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
16
11
2018
revised:
21
03
2019
accepted:
22
03
2019
pubmed:
12
4
2019
medline:
26
2
2020
entrez:
12
4
2019
Statut:
ppublish
Résumé
Tumour repopulation is recognized as a crucial event in tumour relapse where therapy-sensitive dying cancer cells influence the tumour microenvironment to sustain therapy-resistant cancer cell growth. Recent studies highlight the role of the oncometabolites succinate, fumarate, and 2-hydroxyglutarate in the aggressiveness of cancer cells and in the worsening of the patient's clinical outcome. These oncometabolites can be produced and secreted by cancer and/or surrounding cells, modifying the tumour microenvironment and sustaining an invasive neoplastic phenotype. In this review, we report recent findings concerning the role in cancer development of succinate, fumarate, and 2-hydroxyglutarate and the regulation of their related enzymes succinate dehydrogenase, fumarate hydratase, and isocitrate dehydrogenase. We propose that oncometabolites are crucially involved in tumour repopulation. The study of the mechanisms underlying the relationship between oncometabolites and tumour repopulation is fundamental for identifying efficient anti-cancer therapeutic strategies and novel serum biomarkers in order to overcome cancer relapse.
Substances chimiques
Isocitrate Dehydrogenase
EC 1.1.1.41
Succinate Dehydrogenase
EC 1.3.99.1
Fumarate Hydratase
EC 4.2.1.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1530-1546Informations de copyright
© 2019 Cambridge Philosophical Society.