Copper Sulfide Facilitates Hepatobiliary Clearance of Gold Nanoparticles through the Copper-Transporting ATPase ATP7B.
ATP7B
copper sulfide nanoparticle
gold nanoparticle
hepatobiliary excretion
nanoconjugate
Journal
ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589
Informations de publication
Date de publication:
28 05 2019
28 05 2019
Historique:
pubmed:
12
4
2019
medline:
20
8
2020
entrez:
12
4
2019
Statut:
ppublish
Résumé
Metallic gold (Au) nanoparticles have great potential for a wide variety of biomedical applications. Yet, slow clearance of Au nanoparticles significantly hinders their clinical translation. Herein, we describe a strategy of utilizing the endogenous copper (Cu) clearance to improve the elimination of Au nanoparticles. Our mechanistic study reveals that a Cu-transporting P-type ATPase, ATP7B, mediates the exocytosis of CuS nanoparticles into bile canaliculi for their rapid hepatobiliary excretion. The efflux of CuS nanoparticles is adopted to facilitate the hepatobiliary clearance of Au nanoparticles through CuS-Au conjugation. Using two different CuS-Au nanoconjugates, we demonstrate that CuS increases the biliary Au excretion of CuS-Au nanospheres or CuS-Au nanorods in mice or rats in comparison to that of their respective unconjugated Au nanoparticles postintravenous injection. The current CuS-Au conjugation approach provides a feasible strategy to enhance the hepatobiliary clearance of Au nanoparticles that may be applicable to various structures.
Identifiants
pubmed: 30973228
doi: 10.1021/acsnano.9b01154
pmc: PMC8325778
mid: NIHMS1724638
doi:
Substances chimiques
Sulfides
0
Gold
7440-57-5
Copper
789U1901C5
Copper-Transporting ATPases
EC 7.2.2.8
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5720-5730Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103430
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB018748
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM061988
Pays : United States
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