A new para-quinone-type flavan from the leaves of Ilex centrochinensis and its anti-inflammatory activities.

Animals Anti-Inflammatory Agents / pharmacology Flavonoids / chemistry Ilex / chemistry Mice Plant Leaves / chemistry RAW 264.7 Cells
None (2S)-7-methoxy-3′,4′-dihydroxy-5,8-quinoflavan Aquifoliaceae anti-inflammatory activity cytotoxic activity

Journal

Journal of Asian natural products research
ISSN: 1477-2213
Titre abrégé: J Asian Nat Prod Res
Pays: England
ID NLM: 100888334

Informations de publication

Date de publication:
Jan 2019
Historique:
entrez: 12 4 2019
pubmed: 12 4 2019
medline: 11 9 2019
Statut: ppublish

Résumé

A new para-quinone-type flavan, (2S)-7-methoxy-3',4'-dihydroxy-5,8-quinoflavan (1), together with three known compounds, were isolated from the leaves of Ilex centrochinensis. Their structures were elucidated by detailed spectroscopic analyses for new structure and in comparison with published data for known compounds. Moreover, the new compound was evaluated its cytotoxic and anti-inflammatory activities in vitro on LPS induced RAW 264.7 cells and the results showed that 1 has promising anti-inflammatory activities.

Identifiants

DOI: 10.1080/10286020.2018.1453504 PMID: 30973279
pubmed: 30973279
doi: 10.1080/10286020.2018.1453504
doi:

Substances chimiques

Anti-Inflammatory Agents 0
Flavonoids 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

86-92

Auteurs

Hui Long (H)

a National & Local Joint Engineering Research Center for High-throughput Drug Screening Technology , Wuhan 430062 , China.
b Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources , Wuhan 430062 , China.

Qin-Fang Yan (QF)

a National & Local Joint Engineering Research Center for High-throughput Drug Screening Technology , Wuhan 430062 , China.
b Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources , Wuhan 430062 , China.

Ze-Hua Hu (ZH)

d Medical School , Hubei University for Nationalities , Enshi 445000 , China.

Qiang Zhang (Q)

a National & Local Joint Engineering Research Center for High-throughput Drug Screening Technology , Wuhan 430062 , China.
b Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources , Wuhan 430062 , China.

Yu Chen (Y)

a National & Local Joint Engineering Research Center for High-throughput Drug Screening Technology , Wuhan 430062 , China.
b Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources , Wuhan 430062 , China.

Lu-Jun Li (LJ)

a National & Local Joint Engineering Research Center for High-throughput Drug Screening Technology , Wuhan 430062 , China.
b Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources , Wuhan 430062 , China.
c Hubei Key Laboratory of Bio-Technology of Traditional Chinese Medicine , Hubei University , Wuhan 430062 , China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A new para-quinone-type flavan from the leaves...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › A new para-quinone-type flavan from the leaves...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › A new para-quinone-type flavan from the leaves...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Aquifoliaceae › Ilex › A new para-quinone-type flavan from the leaves...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A new para-quinone-type flavan from the leaves...
questionsmedicales.fr › Structures de plante › Parties aériennes de plante › Feuilles de plante › A new para-quinone-type flavan from the leaves...
questionsmedicales.fr › Cellules › Cellules RAW 264.7 › A new para-quinone-type flavan from the leaves...