Synchronized On/Off Switching of Four Binding Sites for Water in a Molecular Solomon Link.
cooperativity
molecular switches
molecular topology
supramolecular chemistry
water recognition
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
11 06 2019
11 06 2019
Historique:
received:
20
02
2019
pubmed:
12
4
2019
medline:
12
4
2019
entrez:
12
4
2019
Statut:
ppublish
Résumé
A molecular Solomon link adopts different conformations in acetonitrile (1) and in water (2). Contrary to expectations, the main driving force of the transformation is not the change in medium polarity, but the cooperative binding of about four molecules of water, forming a tiny droplet in the central cavity of 2. Mechanistic studies reveal that the four binding sites can simultaneously switch between an inactive state (unable to bind water) and an active state (able to bind water) during the transformation. Spatial and temporal coordination of switching events is commonly observed in biological systems but has been rarely achieved in artificial systems. Here, the concerted activation of the four switchable sites is controlled by the topology of the whole molecule.
Identifiants
pubmed: 30973659
doi: 10.1002/anie.201902278
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8053-8057Subventions
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : PZ00P2_161270
Pays : International
Organisme : Ministerio de Economía y Competitividad
ID : CTQ2014-57393-C2-1-P
Pays : International
Organisme : Ministerio de Economía y Competitividad
ID : CTQ2017-85821-R FEDER
Pays : International
Informations de copyright
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.