Cumulative Incidence of Orofacial Manifestations in Early Juvenile Idiopathic Arthritis: A Regional, Three-Year Cohort Study.


Journal

Arthritis care & research
ISSN: 2151-4658
Titre abrégé: Arthritis Care Res (Hoboken)
Pays: United States
ID NLM: 101518086

Informations de publication

Date de publication:
07 2020
Historique:
received: 25 05 2018
accepted: 02 04 2019
pubmed: 12 4 2019
medline: 3 10 2020
entrez: 12 4 2019
Statut: ppublish

Résumé

To estimate the cumulative incidence of arthritis-induced orofacial symptoms, dysfunction, and dentofacial deformities in growing individuals with juvenile idiopathic arthritis (JIA) in a 36-month regional cohort study and to identify predictors for the development of arthritis-induced dentofacial deformities. Data were retrieved from the Aarhus JIA temporomandibular joint (TMJ) cohort register, which contains standardized, longitudinal, observational data regarding orofacial conditions in patients with JIA (n = 1,040). This regional cohort represents the majority of all subjects with JIA from the western part of Denmark between 1990 and 2016, regardless of TMJ arthritis status. Cumulative incidences of orofacial conditions were reported using Kaplan-Meier methods, and predictors for dentofacial deformity were identified using Cox proportional hazards analysis. Follow-up data from 351 subjects for 36 months were included in this study. Median age at first clinical examination was 6.6 years (interquartile range 4.8-9.9 years). Orofacial symptoms and dysfunctions were common findings at 36 months after the first clinical examination and 5 years after JIA onset, with a cumulative incidence of 38% and 53%, respectively. Dentofacial deformities were found in 35% of subjects at the 36-month follow-up and were significantly associated with the presence of orofacial dysfunction. Orofacial conditions were frequently observed in individuals with JIA and were represented in all JIA subcategories in this regional study. One-third of subjects had arthritis-induced dentofacial deformities that required orthopedic appliance treatment at the 36-month follow-up.

Identifiants

pubmed: 30973675
doi: 10.1002/acr.23899
doi:

Types de publication

Journal Article Observational Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

907-916

Informations de copyright

© 2019, American College of Rheumatology.

Références

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Auteurs

Peter Stoustrup (P)

Aarhus University, Aarhus, Denmark.

Mia Glerup (M)

Aarhus University Hospital, Aarhus, Denmark.

Anders E Bilgrau (AE)

Aalborg University, Aalborg, Denmark.

Annelise Küseler (A)

Aarhus University, Aarhus, Denmark.

Carlalberta Verna (C)

University of Basel, Basel, Switzerland.

Anne E Christensen (AE)

Odense University Hospital, Odense, Denmark.

Kasper D Kristensen (KD)

Aarhus University, Aarhus, Denmark.

Sven Erik Nørholt (SE)

Aarhus University Hospital and Aarhus University, Aarhus, Denmark.

Marinka Twilt (M)

University of Calgary and Alberta Children's Hospital, Calgary, Canada.

Troels Herlin (T)

Aarhus University Hospital, Aarhus, Denmark.

Thomas K Pedersen (TK)

Aarhus University Hospital and Aarhus University, Aarhus, Denmark.

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