Physiological levels of chromogranin A prevent doxorubicin-induced cardiotoxicity without impairing its anticancer activity.

Animals Antibiotics, Antineoplastic / adverse effects Apoptosis / drug effects Chromogranin A / metabolism Doxorubicin / adverse effects Female Heart / drug effects Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Myocytes, Cardiac / drug effects Rats Rats, Wistar
cancer cardioprotection intracellular signaling

Journal

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484

Informations de publication

Date de publication:
06 2019
Historique:
pubmed: 12 4 2019
medline: 20 6 2020
entrez: 12 4 2019
Statut: ppublish

Résumé

The clinical use of doxorubicin (Doxo), a widely used anticancer chemotherapeutic drug, is limited by dose-dependent cardiotoxicity. We have investigated whether chromogranin A (CgA), a cardioregulatory protein released in the blood by the neuroendocrine system and by the heart itself, may contribute to regulation of the cardiotoxic and antitumor activities of Doxo. The effects of a physiologic dose of full-length recombinant CgA on Doxo-induced cardiotoxicity and antitumor activity were investigated in rats using

Identifiants

DOI: 10.1096/fj.201802707R PMID: 30973759
pubmed: 30973759
doi: 10.1096/fj.201802707R
doi:

Substances chimiques

Antibiotics, Antineoplastic 0
Chromogranin A 0
Doxorubicin 80168379AG

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

7734-7747

Auteurs

Carmine Rocca (C)

Laboratory of Cellular and Molecular Cardiac Pathophysiology, Department of Biology, Ecology, and Earth Science, University of Calabria, Rende (Cosenza), Italy.

Francesco Scavello (F)

Laboratory of Cellular and Molecular Cardiac Pathophysiology, Department of Biology, Ecology, and Earth Science, University of Calabria, Rende (Cosenza), Italy.

Barbara Colombo (B)

Division of Experimental Oncology, Vita-Salute San Raffaele University-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy.

Anna Maria Gasparri (AM)

Division of Experimental Oncology, Vita-Salute San Raffaele University-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy.

Alice Dallatomasina (A)

Division of Experimental Oncology, Vita-Salute San Raffaele University-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy.

Maria Concetta Granieri (MC)

Laboratory of Cellular and Molecular Cardiac Pathophysiology, Department of Biology, Ecology, and Earth Science, University of Calabria, Rende (Cosenza), Italy.

Daniela Amelio (D)

Laboratory of Cellular and Molecular Cardiac Pathophysiology, Department of Biology, Ecology, and Earth Science, University of Calabria, Rende (Cosenza), Italy.

Teresa Pasqua (T)

Laboratory of Cellular and Molecular Cardiac Pathophysiology, Department of Biology, Ecology, and Earth Science, University of Calabria, Rende (Cosenza), Italy.

Maria Carmela Cerra (MC)

Laboratory of Cellular and Molecular Cardiac Pathophysiology, Department of Biology, Ecology, and Earth Science, University of Calabria, Rende (Cosenza), Italy.
National Institute of Cardiovascular Research (INRC), Bologna, Italy.

Bruno Tota (B)

Laboratory of Cellular and Molecular Cardiac Pathophysiology, Department of Biology, Ecology, and Earth Science, University of Calabria, Rende (Cosenza), Italy.
National Institute of Cardiovascular Research (INRC), Bologna, Italy.

Angelo Corti (A)

Division of Experimental Oncology, Vita-Salute San Raffaele University-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy.

Tommaso Angelone (T)

Laboratory of Cellular and Molecular Cardiac Pathophysiology, Department of Biology, Ecology, and Earth Science, University of Calabria, Rende (Cosenza), Italy.
National Institute of Cardiovascular Research (INRC), Bologna, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Physiological levels of chromogranin A prevent...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antibiotiques antinéoplasiques › Physiological levels of chromogranin A prevent...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Physiological levels of chromogranin A prevent...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Chromogranine A › Physiological levels of chromogranin A prevent...
questionsmedicales.fr › Glucides › Hétérosides › Aminosides › Anthracyclines › Daunorubicine › Doxorubicine › Physiological levels of chromogranin A prevent...
questionsmedicales.fr › Système cardiovasculaire › Coeur › Physiological levels of chromogranin A prevent...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Physiological levels of chromogranin A prevent...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Physiological levels of chromogranin A prevent...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Physiological levels of chromogranin A prevent...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Physiological levels of chromogranin A prevent...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Physiological levels of chromogranin A prevent...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Wistar › Physiological levels of chromogranin A prevent...