Population Pharmacokinetics of Pemetrexed in Adult Non-Small Cell Lung Cancer in Indian Patients.

Adult Aged Antineoplastic Agents / pharmacokinetics Bayes Theorem Body Surface Area Carcinoma, Non-Small-Cell Lung / drug therapy Female Humans Infusions, Intravenous / methods Lung Neoplasms / drug therapy Male Middle Aged Models, Biological Pemetrexed / pharmacokinetics Young Adult
BAYES analysis full covariate modeling pemetrexed population pharmacokinetics

Journal

Journal of clinical pharmacology
ISSN: 1552-4604
Titre abrégé: J Clin Pharmacol
Pays: England
ID NLM: 0366372

Informations de publication

Date de publication:
09 2019
Historique:
received: 18 12 2018
accepted: 25 03 2019
pubmed: 12 4 2019
medline: 28 7 2020
entrez: 12 4 2019
Statut: ppublish

Résumé

The objective of the study was to develop a population pharmacokinetic model of pemetrexed and identify factors contributing to variability in exposure in Indian patients. Plasma samples were obtained from a cohort of 85 patients following 500 mg/m

Identifiants

DOI: 10.1002/jcph.1417 PMID: 30973978
pubmed: 30973978
doi: 10.1002/jcph.1417
doi:

Substances chimiques

Antineoplastic Agents 0
Pemetrexed 04Q9AIZ7NO

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1216-1224

Informations de copyright

© 2019, The American College of Clinical Pharmacology.

Auteurs

Meenakshi Srinivasan (M)

University of North Texas Health Science Center, Fort Worth, TX, USA.

Ayyappa Chaturvedula (A)

University of North Texas Health Science Center, Fort Worth, TX, USA.

Michael J Fossler (MJ)

Trevena Inc, Chesterbrook, PA, USA.

Anand Patil (A)

Tata Memorial Centre, Mumbai, India.

Vikram Gota (V)

Tata Memorial Centre, Mumbai, India.

Kumar Prabhash (K)

Tata Memorial Centre, Mumbai, India.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Population Pharmacokinetics of Pemetrexed in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Population Pharmacokinetics of Pemetrexed in...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Population Pharmacokinetics of Pemetrexed in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Théorème de Bayes › Population Pharmacokinetics of Pemetrexed in...
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Poids et mesures du corps › Surface corporelle › Population Pharmacokinetics of Pemetrexed in...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tumeurs des bronches › Carcinome bronchogénique › Carcinome pulmonaire non à petites cellules › Population Pharmacokinetics of Pemetrexed in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Population Pharmacokinetics of Pemetrexed in...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Perfusions parentérales › Perfusions veineuses › Population Pharmacokinetics of Pemetrexed in...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Population Pharmacokinetics of Pemetrexed in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Population Pharmacokinetics of Pemetrexed in...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Population Pharmacokinetics of Pemetrexed in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés dicarboxyliques › Glutamates › Pémétrexed › Population Pharmacokinetics of Pemetrexed in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Population Pharmacokinetics of Pemetrexed in...