Tannic acid as a natural antioxidant compound: Discovery of a potent metabolic enzyme inhibitor for a new therapeutic approach in diabetes and Alzheimer's disease.
anticholinergics
antidiabetic
enzyme inhibition
metabolic enzymes
tannic acid
Journal
Journal of biochemical and molecular toxicology
ISSN: 1099-0461
Titre abrégé: J Biochem Mol Toxicol
Pays: United States
ID NLM: 9717231
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
01
12
2018
revised:
11
01
2019
accepted:
25
03
2019
pubmed:
12
4
2019
medline:
14
1
2020
entrez:
12
4
2019
Statut:
ppublish
Résumé
Multiple studies have been recorded on the synthesis and design of multi-aim anti-Alzheimer molecules. Using dual butyrylcholinesterase/acetylcholinesterase inhibitor molecules has attracted more interest in the therapy for Alzheimer's disease. In this study, a tannic acid compound showed excellent inhibitory effects against acetylcholine esterase (AChE), α-glycosidase, α-amylase, and butyrylcholinesterase (BChE). IC
Substances chimiques
Antioxidants
0
Enzyme Inhibitors
0
Tannins
0
Acetylcholinesterase
EC 3.1.1.7
Butyrylcholinesterase
EC 3.1.1.8
Amylases
EC 3.2.1.-
alpha-Glucosidases
EC 3.2.1.20
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e22340Informations de copyright
© 2019 Wiley Periodicals, Inc.