Advances in respiratory virus therapeutics - A meeting report from the 6th isirv Antiviral Group conference.
Antiviral therapy
Coronavirus
Host-directed therapeutics
Influenza
Respiratory syncytial virus
Journal
Antiviral research
ISSN: 1872-9096
Titre abrégé: Antiviral Res
Pays: Netherlands
ID NLM: 8109699
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
29
03
2019
accepted:
06
04
2019
pubmed:
12
4
2019
medline:
15
5
2020
entrez:
12
4
2019
Statut:
ppublish
Résumé
The International Society for Influenza and other Respiratory Virus Diseases held its 6th Antiviral Group (isirv-AVG) conference in Rockville, Maryland, November 13-15, 2018. The three-day program was focused on therapeutics towards seasonal and pandemic influenza, respiratory syncytial virus, coronaviruses including MERS-CoV and SARS-CoV, human rhinovirus, and other respiratory viruses. Updates were presented on several influenza antivirals including baloxavir, CC-42344, VIS410, immunoglobulin, immune plasma, MHAA4549A, pimodivir (JNJ-63623872), umifenovir, and HA minibinders; RSV antivirals including presatovir (GS-5806), ziresovir (AK0529), lumicitabine (ALS-008176), JNJ-53718678, JNJ-64417184, and EDP-938; broad spectrum antivirals such as favipiravir, VH244, remdesivir, and EIDD-1931/EIDD-2801; and host directed strategies including nitazoxanide, eritoran, and diltiazem. Other topics included considerations of novel endpoints such as ordinal scales and patient reported outcomes (PRO), and study design issues, and other regulatory considerations for antiviral drug development. The aim of this report is to provide a summary of the presentations given at this meeting.
Identifiants
pubmed: 30974127
pii: S0166-3542(19)30158-5
doi: 10.1016/j.antiviral.2019.04.006
pmc: PMC7132446
pii:
doi:
Substances chimiques
Antiviral Agents
0
remdesivir
3QKI37EEHE
Adenosine Monophosphate
415SHH325A
Alanine
OF5P57N2ZX
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
45-67Subventions
Organisme : NIAID NIH HHS
ID : T32 AI095207
Pays : United States
Informations de copyright
Published by Elsevier B.V.
Références
Sci Rep. 2017 Mar 06;7:43395
pubmed: 28262699
J Clin Microbiol. 2005 May;43(5):2356-62
pubmed: 15872266
Transpl Infect Dis. 2016 Apr;18(2):210-5
pubmed: 26923867
Front Microbiol. 2018 Dec 06;9:3026
pubmed: 30574137
Clin Infect Dis. 2014 Jan;58(2):214-24
pubmed: 24186906
Influenza Other Respir Viruses. 2017 Nov;11(6):525-530
pubmed: 28990339
J Virol. 2008 Sep;82(17):8721-32
pubmed: 18579604
Lancet Infect Dis. 2018 Apr;18(4):410-418
pubmed: 29329957
Antiviral Res. 2014 Jul;107:84-94
pubmed: 24769245
Sci Transl Med. 2016 Feb 17;8(326):326ra21
pubmed: 26888429
PLoS One. 2012;7(1):e29652
pubmed: 22276122
N Engl J Med. 2015 Nov 19;373(21):2048-58
pubmed: 26580997
Am J Obstet Gynecol. 2011 Jun;204(6):524.e1-4
pubmed: 21457910
Value Health. 2018 Feb;21(2):210-218
pubmed: 29477403
Antimicrob Agents Chemother. 2018 Jul 27;62(8):
pubmed: 29891600
Clin Infect Dis. 2011 Feb 15;52(4):447-56
pubmed: 21248066
mBio. 2018 Mar 13;9(2):
pubmed: 29535197
Cell Physiol Biochem. 2018;51(5):2377-2396
pubmed: 30537741
J Clin Virol. 2010 Jan;47(1):23-8
pubmed: 19962344
Antiviral Res. 2017 Aug;144:48-56
pubmed: 28535933
MAbs. 2016 Jul;8(5):991-7
pubmed: 27031797
HIV Med. 2016 Jan;17(1):28-35
pubmed: 26200570
J Infect Dis. 2018 Jul 24;218(5):748-756
pubmed: 29684148
J Virol. 2013 Oct;87(19):10524-38
pubmed: 23824822
Influenza Other Respir Viruses. 2018 Mar;12(2):267-278
pubmed: 29265727
Nature. 2013 May 23;497(7450):498-502
pubmed: 23636320
Nature. 2017 Oct 5;550(7674):74-79
pubmed: 28953867
Antimicrob Agents Chemother. 2017 Oct 24;61(11):
pubmed: 28807912
J Infect Dis. 2015 Dec 15;212(12):1904-13
pubmed: 26198719
Sci Rep. 2018 Jun 25;8(1):9633
pubmed: 29941893
Sci Transl Med. 2017 Jun 28;9(396):
pubmed: 28659436
Front Immunol. 2019 Jan 29;10:60
pubmed: 30761132
Antimicrob Agents Chemother. 2016 Aug 22;60(9):5504-14
pubmed: 27381402
JCI Insight. 2018 Dec 20;3(24):
pubmed: 30568032
Nat Med. 2013 Oct;19(10):1313-7
pubmed: 24013700
Trials. 2018 Jan 30;19(1):81
pubmed: 29382391
Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):10890-5
pubmed: 26283346
Clin Trials. 2017 Jun;14(3):264-276
pubmed: 28397569
Springerplus. 2015 Nov 19;4:709
pubmed: 26618098
Thorax. 2004 Mar;59(3):252-6
pubmed: 14985565
Nature. 2009 Apr 16;458(7240):914-8
pubmed: 19194459
Ann Intern Med. 2006 Oct 17;145(8):599-609
pubmed: 16940336
J Med Chem. 2017 Mar 9;60(5):1648-1661
pubmed: 28124907
BMC Anesthesiol. 2016 Jul 12;16(1):36
pubmed: 27405596
J Gen Virol. 2013 Aug;94(Pt 8):1749-1760
pubmed: 23620378
Antivir Ther. 2018;23(4):335-344
pubmed: 29244026
Drugs. 2010 Oct 1;70(14):1885-915
pubmed: 20836579
Chest. 2013 Aug;144(2):464-473
pubmed: 23450336
Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19944-9
pubmed: 19036930
PLoS One. 2018 Nov 15;13(11):e0206831
pubmed: 30439974
mBio. 2017 Apr 4;8(2):
pubmed: 28377531
Expert Opin Investig Drugs. 2017 Jan;26(1):63-73
pubmed: 27918208
Lancet Respir Med. 2017 Feb;5(2):135-146
pubmed: 28094141
J Infect Dis. 2010 Jun 1;201(11):1654-62
pubmed: 20423224
Antimicrob Agents Chemother. 2015 Dec 14;60(3):1264-73
pubmed: 26666922
Clin Infect Dis. 2019 Nov 13;69(11):1903-1911
pubmed: 30753384
Int J Infect Dis. 2014 Mar;20:42-6
pubmed: 24406736
Lancet. 2005 Oct 1;366(9492):1175-81
pubmed: 16198766
Clin Ther. 2018 Aug;40(8):1268-1281
pubmed: 30077340
Lancet Infect Dis. 2014 Jul;14(7):609-18
pubmed: 24852376
J Infect Dis. 2005 Jun 1;191(11):1861-8
pubmed: 15871119
J Gen Virol. 2014 Mar;95(Pt 3):571-577
pubmed: 24323636
Chest. 2017 May;151(5):1069-1080
pubmed: 27884765
Antiviral Res. 2018 Jan;149:118-142
pubmed: 29162476
mBio. 2018 Mar 6;9(2):
pubmed: 29511076
N Engl J Med. 2017 Feb 9;376(6):584-594
pubmed: 28177862
Lancet. 2017 Sep 2;390(10098):946-958
pubmed: 28689664
Science. 2018 Nov 2;362(6414):598-602
pubmed: 30385580
J Infect Dis. 2014 Jun 15;209(12):1873-81
pubmed: 24482398
Nat Microbiol. 2016 Nov 28;2:16226
pubmed: 27892925
J Immunol. 2008 Apr 15;180(8):5662-9
pubmed: 18390751
Expert Opin Biol Ther. 2018 Jun;18(6):665-680
pubmed: 29624084
Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3048-53
pubmed: 26976607
Antiviral Res. 2013 Nov;100(2):446-54
pubmed: 24084488
Antimicrob Agents Chemother. 2017 Aug 24;61(9):
pubmed: 28652242
Nature. 2016 Mar 17;531(7594):381-5
pubmed: 26934220
Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):206-214
pubmed: 28003465
J Infect. 2013 Dec;67(6):606-16
pubmed: 24096239
J Infect Dis. 2019 Mar 15;219(7):1026-1034
pubmed: 30428049
Lancet. 2015 May 2;385(9979):1729-1737
pubmed: 25640810
Sci Rep. 2017 Aug 4;7(1):7345
pubmed: 28779075
Cochrane Database Syst Rev. 2016 Mar 07;3:CD010406
pubmed: 26950335
Br J Clin Pharmacol. 1996 Dec;42(6):697-705
pubmed: 8971424
Cell Rep. 2015 Jun 30;11(12):1941-52
pubmed: 26095366
Lancet Infect Dis. 2018 Nov;18(11):1191-1210
pubmed: 30243584
Antiviral Res. 2018 Dec;160:109-117
pubmed: 30316915
BMC Infect Dis. 2016 Apr 21;16:174
pubmed: 27097824
Curr Drug Discov Technol. 2018;15(3):201-213
pubmed: 28748751
J Infect Dis. 2011 Oct 1;204(7):996-1002
pubmed: 21881113
Antimicrob Agents Chemother. 2014 Aug;58(8):4875-84
pubmed: 24841269
J Virol. 2008 Apr;82(7):3220-35
pubmed: 18199635
J Infect Dis. 1990 Apr;161(4):640-6
pubmed: 2319164
Antimicrob Agents Chemother. 2015 Mar;59(3):1569-82
pubmed: 25547360
Sci Rep. 2018 Jul 11;8(1):10425
pubmed: 29992955
Antiviral Res. 2014 Oct;110:94-103
pubmed: 25108173
J Virol. 2008 Sep;82(17):8570-8
pubmed: 18579602
N Engl J Med. 2014 Aug 21;371(8):711-22
pubmed: 25140957
Nat Med. 2015 Dec;21(12):1508-13
pubmed: 26552008
Int J Infect Dis. 2016 Feb;43:77-84
pubmed: 26775570
mBio. 2018 Apr 24;9(2):
pubmed: 29691337
MMWR Morb Mortal Wkly Rep. 2009 Apr 17;58(14):369-74
pubmed: 19373198
Am J Obstet Gynecol. 2011 Jun;204(6 Suppl 1):S84-8
pubmed: 21492826
J Med Chem. 2017 May 11;60(9):3533-3551
pubmed: 28118010
Lancet Respir Med. 2017 Jun;5(6):500-511
pubmed: 28522352
Crit Care Med. 2014 Feb;42(2):313-21
pubmed: 24105455
J Antimicrob Chemother. 2019 Mar 1;74(3):654-662
pubmed: 30476172
Clin Infect Dis. 2020 Dec 17;71(10):e594-e603
pubmed: 32201897
N Engl J Med. 2005 Apr 28;352(17):1749-59
pubmed: 15858184
Antiviral Res. 2018 Feb;150:202-216
pubmed: 29325970
PLoS One. 2014 Nov 21;9(11):e113100
pubmed: 25415360
J Virol. 2007 Jul;81(14):7410-23
pubmed: 17507479
N Engl J Med. 2018 Sep 6;379(10):913-923
pubmed: 30184455
Health Qual Life Outcomes. 2006 Oct 11;4:79
pubmed: 17034633
Euro Surveill. 2019 Jan;24(3):
pubmed: 30670144
Antiviral Res. 2017 Oct;146:12-20
pubmed: 28802866
Clin Infect Dis. 2014 Dec 15;59(12):e172-85
pubmed: 25115871
Can Respir J. 2018 Jun 19;2018:2732017
pubmed: 30018677
Clin Infect Dis. 2018 Mar 19;66(7):1042-1044
pubmed: 29088341
Science. 2011 May 13;332(6031):816-21
pubmed: 21566186
Clin Infect Dis. 2009 Dec 15;49(12):1828-35
pubmed: 19911968
J Clin Microbiol. 2003 Feb;41(2):742-50
pubmed: 12574276
Eur J Med Chem. 2017 Jan 27;126:154-159
pubmed: 27750149
Sci Rep. 2017 Jan 20;7:40791
pubmed: 28106157
N Engl J Med. 2009 Feb 5;360(6):588-98
pubmed: 19196675
Am J Respir Crit Care Med. 2018 Mar 15;197(6):757-767
pubmed: 29161116
EBioMedicine. 2019 Feb;40:574-582
pubmed: 30638863
Am J Respir Crit Care Med. 2010 Nov 15;182(10):1305-14
pubmed: 20622030
Lancet Infect Dis. 2014 Nov;14(11):1090-1095
pubmed: 25278221
J Virol. 2008 Mar;82(5):2274-85
pubmed: 18094188