Cytokine alterations in first-onset postpartum psychosis-clues for underlying immune dysregulation.
Acute Psychosis
Chemokine
Cytokine
Depression
Immune
Mania
Postpartum psychosis
Journal
Asian journal of psychiatry
ISSN: 1876-2026
Titre abrégé: Asian J Psychiatr
Pays: Netherlands
ID NLM: 101517820
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
08
12
2018
revised:
16
02
2019
accepted:
25
03
2019
pubmed:
12
4
2019
medline:
4
12
2019
entrez:
12
4
2019
Statut:
ppublish
Résumé
Emerging evidence suggests a possible role for immune system dysregulation in the pathogenesis of postpartum psychosis (PP) but the evidence is limited. The current study sought to determine the serum cytokines/ chemokine changes associated with first-onset PP. Women with first onset PP were recruited as cases and the cytokines/ chemokine changes were compared against healthy postpartum (HP) and healthy non-postpartum (HNP) women.There were 20 subjects in each of the three groups. Levels of serum cytokines and Monocyte Chemoattractant Protein-1 (MCP-1) were estimated with a cytometric beadarray assay. HP group showed significantly elevated levels of interleukin (IL)-6 as compared to HNP group. Whereas, the first onset PP group showed significantly elevated levels of both IL-6 and IL-8 as compared to HNP group. Postpartum period appears to be a state of altered immune functioning considering the elevated level of IL-6 in both HP and PP group. Additionally, IL-8 appears to play a role in the manifestation of PP. Our study highlights the immune alterations associated with first-onset PP.
Sections du résumé
BACKGROUND
BACKGROUND
Emerging evidence suggests a possible role for immune system dysregulation in the pathogenesis of postpartum psychosis (PP) but the evidence is limited. The current study sought to determine the serum cytokines/ chemokine changes associated with first-onset PP.
METHODS
METHODS
Women with first onset PP were recruited as cases and the cytokines/ chemokine changes were compared against healthy postpartum (HP) and healthy non-postpartum (HNP) women.There were 20 subjects in each of the three groups. Levels of serum cytokines and Monocyte Chemoattractant Protein-1 (MCP-1) were estimated with a cytometric beadarray assay.
RESULTS
RESULTS
HP group showed significantly elevated levels of interleukin (IL)-6 as compared to HNP group. Whereas, the first onset PP group showed significantly elevated levels of both IL-6 and IL-8 as compared to HNP group.
CONCLUSION
CONCLUSIONS
Postpartum period appears to be a state of altered immune functioning considering the elevated level of IL-6 in both HP and PP group. Additionally, IL-8 appears to play a role in the manifestation of PP. Our study highlights the immune alterations associated with first-onset PP.
Identifiants
pubmed: 30974307
pii: S1876-2018(18)31043-8
doi: 10.1016/j.ajp.2019.03.012
pii:
doi:
Substances chimiques
CXCL8 protein, human
0
Cytokines
0
IL6 protein, human
0
Interleukin-6
0
Interleukin-8
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
74-78Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.