Serine/Threonine Protein Kinase STK16.
Golgi apparatus
STK16
cell cycle
fatty acylation
kinase
phosphorylation
protein secretion and sorting
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Apr 2019
10 Apr 2019
Historique:
received:
25
03
2019
revised:
05
04
2019
accepted:
08
04
2019
entrez:
13
4
2019
pubmed:
13
4
2019
medline:
31
7
2019
Statut:
epublish
Résumé
STK16 (Ser/Thr kinase 16, also known as Krct/PKL12/MPSK1/TSF-1) is a myristoylated and palmitoylated Ser/Thr protein kinase that is ubiquitously expressed and conserved among all eukaryotes. STK16 is distantly related to the other kinases and belongs to the NAK kinase family that has an atypical activation loop architecture. As a membrane-associated protein that is primarily localized to the Golgi, STK16 has been shown to participate in the TGF-β signaling pathway, TGN protein secretion and sorting, as well as cell cycle and Golgi assembly regulation. This review aims to provide a comprehensive summary of the progress made in recent research about STK16, ranging from its distribution, molecular characterization, post-translational modification (fatty acylation and phosphorylation), interactors (GlcNAcK/DRG1/MAL2/Actin/WDR1), and related functions. As a relatively underexplored kinase, more studies are encouraged to unravel its regulation mechanisms and cellular functions.
Identifiants
pubmed: 30974739
pii: ijms20071760
doi: 10.3390/ijms20071760
pmc: PMC6480182
pii:
doi:
Substances chimiques
Transcription Factors
0
Protein Serine-Threonine Kinases
EC 2.7.11.1
STK16 protein, human
EC 2.7.11.1
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Key R&D Program of China
ID : 2016YFA0400900
Organisme : the Key Program of 13th five-year plan, CASHIPS
ID : KP-2017-26
Organisme : CASHIPS Director's Fund
ID : YZJJ201704
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