MAPK/ERK Signaling in Regulation of Renal Differentiation.
MAPK/ERK signaling
differentiation
extracellular signal-regulated kinase
intracellular signaling
kidney development
nephrogenesis
progenitor cells
self-renewal
ureteric bud branching morphogenesis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Apr 2019
10 Apr 2019
Historique:
received:
11
03
2019
revised:
04
04
2019
accepted:
08
04
2019
entrez:
13
4
2019
pubmed:
13
4
2019
medline:
31
7
2019
Statut:
epublish
Résumé
Congenital anomalies of the kidney and urinary tract (CAKUT) are common birth defects derived from abnormalities in renal differentiation during embryogenesis. CAKUT is the major cause of end-stage renal disease and chronic kidney diseases in children, but its genetic causes remain largely unresolved. Here we discuss advances in the understanding of how mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) activity contributes to the regulation of ureteric bud branching morphogenesis, which dictates the final size, shape, and nephron number of the kidney. Recent studies also demonstrate that the MAPK/ERK pathway is directly involved in nephrogenesis, regulating both the maintenance and differentiation of the nephrogenic mesenchyme. Interestingly, aberrant MAPK/ERK signaling is linked to many cancers, and recent studies suggest it also plays a role in the most common pediatric renal cancer, Wilms' tumor.
Identifiants
pubmed: 30974877
pii: ijms20071779
doi: 10.3390/ijms20071779
pmc: PMC6479953
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Academy of Finland
ID : 294243
Organisme : Academy of Finland
ID : 309997
Organisme : Jane ja Aatos Erkon Säätiö
ID : 27032014
Organisme : Finnish Liver and Kidney Foundation
ID : 2018
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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