Older-Patient-Specific Cancer Trials: A Pooled Analysis of 2,277 Patients (A151715).
Age Factors
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols
/ administration & dosage
Breast Neoplasms
/ mortality
Chemotherapy, Adjuvant
/ methods
Clinical Trials, Phase III as Topic
/ standards
Disease-Free Survival
Female
Humans
Mastectomy
Neoplasm Recurrence, Local
/ epidemiology
Patient Selection
Proportional Hazards Models
Randomized Controlled Trials as Topic
/ standards
Accrual
Adjuvant
Breast cancer
Clinical trials
Older patients
Journal
The oncologist
ISSN: 1549-490X
Titre abrégé: Oncologist
Pays: England
ID NLM: 9607837
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
21
11
2018
accepted:
01
03
2019
pubmed:
13
4
2019
medline:
21
7
2020
entrez:
13
4
2019
Statut:
ppublish
Résumé
Less than 3% of older patients with cancer are enrolled in clinical trials. To reverse this underrepresentation, we compared older patients enrolled with older-patient-specific trials, defined as those designed for older patients with cancer, with those enrolled in age-unspecified trials. We focused on individual patient data from those ≥65 years (younger patients excluded) and included all Alliance phase III adjuvant breast cancer trials from 1985-2012. Among 2,277 patients, 1,014 had been enrolled to older-patient-specific and 1,263 to age-unspecified trials. The median age (range) in the older-patient-specific trials was 72 (65-89) years compared with 68 (65-84) years in the cohort of older patients in age-unspecified trials; Older-patient-specific trials appear to address this underrepresentation of older patients with ostensibly comparable outcomes.
Sections du résumé
BACKGROUND
Less than 3% of older patients with cancer are enrolled in clinical trials. To reverse this underrepresentation, we compared older patients enrolled with older-patient-specific trials, defined as those designed for older patients with cancer, with those enrolled in age-unspecified trials.
MATERIALS AND METHODS
We focused on individual patient data from those ≥65 years (younger patients excluded) and included all Alliance phase III adjuvant breast cancer trials from 1985-2012.
RESULTS
Among 2,277 patients, 1,014 had been enrolled to older-patient-specific and 1,263 to age-unspecified trials. The median age (range) in the older-patient-specific trials was 72 (65-89) years compared with 68 (65-84) years in the cohort of older patients in age-unspecified trials;
CONCLUSION
Older-patient-specific trials appear to address this underrepresentation of older patients with ostensibly comparable outcomes.
Identifiants
pubmed: 30975921
pii: theoncologist.2018-0803
doi: 10.1634/theoncologist.2018-0803
pmc: PMC6656509
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e284-e291Subventions
Organisme : NCI NIH HHS
ID : U10 CA180857
Pays : United States
Organisme : NCI NIH HHS
ID : UG1 CA189823
Pays : United States
Organisme : NCI NIH HHS
ID : UG1 CA233180
Pays : United States
Organisme : NCI NIH HHS
ID : UG1 CA189850
Pays : United States
Organisme : NCI NIH HHS
ID : UG1 CA233373
Pays : United States
Organisme : NCI NIH HHS
ID : U10 CA180867
Pays : United States
Organisme : NCI NIH HHS
ID : U10 CA180838
Pays : United States
Informations de copyright
© AlphaMed Press 2019.
Déclaration de conflit d'intérêts
Disclosures of potential conflicts of interest may be found at the end of this article.
Références
N Engl J Med. 1994 May 5;330(18):1253-9
pubmed: 8080512
N Engl J Med. 1999 Dec 30;341(27):2061-7
pubmed: 10615079
J Clin Oncol. 2003 Mar 15;21(6):976-83
pubmed: 12637460
J Clin Oncol. 2012 Nov 20;30(33):4071-6
pubmed: 22826271
J Clin Oncol. 2003 Apr 1;21(7):1383-9
pubmed: 12663731
N Engl J Med. 2009 May 14;360(20):2055-65
pubmed: 19439741
Rep Pract Oncol Radiother. 2012 Sep 26;18(1):6-10
pubmed: 24381741
J Clin Oncol. 2005 Dec 20;23(36):9113-9
pubmed: 16361618
J Clin Oncol. 2014 Aug 20;32(24):2587-94
pubmed: 25071116
J Clin Oncol. 2014 Aug 1;32(22):2311-7
pubmed: 24934787
J Clin Oncol. 2011 Sep 1;29(25):3366-73
pubmed: 21768458
Oncologist. 2014 Oct;19(10):1069-75
pubmed: 25170014
J Clin Oncol. 2005 Apr 1;23(10):2201-7
pubmed: 15800312
J Clin Oncol. 2011 Dec 10;29(35):4647-53
pubmed: 22067407
J Clin Oncol. 2017 Feb;35(4):421-431
pubmed: 27992272
Cancer. 2002 Sep 1;95(5):989-96
pubmed: 12209681
J Clin Oncol. 2007 May 10;25(14):1858-69
pubmed: 17488984
J Clin Oncol. 2003 Apr 15;21(8):1431-9
pubmed: 12668651
J Clin Oncol. 2003 Jun 15;21(12):2268-75
pubmed: 12805325
Breast Cancer Res Treat. 2006 Jul;98(2):217-22
pubmed: 16538529