Platelet activating factor receptor regulates colitis-induced pulmonary inflammation through the NLRP3 inflammasome.
Animals
Biopsy
Colitis
/ complications
Dextran Sulfate
/ adverse effects
Disease Models, Animal
Disease Susceptibility
Endoscopy
Immunohistochemistry
Inflammasomes
/ metabolism
Inflammatory Bowel Diseases
/ complications
Mice
NLR Family, Pyrin Domain-Containing 3 Protein
/ metabolism
Neutrophil Infiltration
/ immunology
Platelet Membrane Glycoproteins
/ metabolism
Pneumonia
/ etiology
Receptors, G-Protein-Coupled
/ metabolism
Signal Transduction
Journal
Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
25
09
2018
accepted:
24
03
2019
revised:
07
03
2019
pubmed:
13
4
2019
medline:
11
4
2020
entrez:
13
4
2019
Statut:
ppublish
Résumé
Extra-intestinal manifestations (EIM) are common in inflammatory bowel disease (IBD). One such EIM is sub-clinical pulmonary inflammation, which occurs in up to 50% of IBD patients. In animal models of colitis, pulmonary inflammation is driven by neutrophilic infiltrations, primarily in response to the systemic bacteraemia and increased bacterial load in the lungs. Platelet activating factor receptor (PAFR) plays a critical role in regulating pulmonary responses to infection in conditions, such as chronic obstructive pulmonary disease and asthma. We investigated the role of PAFR in pulmonary EIMs of IBD, using dextran sulfate sodium (DSS) and anti-CD40 murine models of colitis. Both models induced neutrophilic inflammation, with increased TNF and IL-1β levels, bacterial load and PAFR protein expression in mouse lungs. Antagonism of PAFR decreased lung neutrophilia, TNF, and IL-1β in an NLRP3 inflammasome-dependent manner. Lipopolysaccharide from phosphorylcholine (ChoP)-positive bacteria induced NLRP3 and caspase-1 proteins in human alveolar epithelial cells, however antagonism of PAFR prevented NLRP3 activation by ChoP. Amoxicillin reduced bacterial populations in the lungs and reduced NLRP3 inflammasome protein levels, but did not reduce PAFR. These data suggest a role for PAFR in microbial pattern recognition and NLRP3 inflammasome signaling in the lung.
Identifiants
pubmed: 30976089
doi: 10.1038/s41385-019-0163-3
pii: S1933-0219(22)00266-5
doi:
Substances chimiques
Inflammasomes
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
Platelet Membrane Glycoproteins
0
Receptors, G-Protein-Coupled
0
platelet activating factor receptor
0
Dextran Sulfate
9042-14-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
862-873Références
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