Current Approaches in the Development of Molecular and Pharmacological Therapies in Craniosynostosis Utilizing Animal Models.
Cranial suture
Craniosynostosis
FGFR2
Molecular therapy
Tyrosine kinase inhibitors
Journal
Molecular syndromology
ISSN: 1661-8769
Titre abrégé: Mol Syndromol
Pays: Switzerland
ID NLM: 101525192
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
entrez:
13
4
2019
pubmed:
13
4
2019
medline:
13
4
2019
Statut:
ppublish
Résumé
The development of the craniofacial skeleton is a spatial and temporal process where cranial sutures play a role in the regulation of morphogenesis and growth. Disruption of these cellular and molecular interactions may lead to craniosynostosis, the premature obliteration of one or more cranial sutures, yielding skull growth restriction and malformation perpendicular to the affected suture. Facial deformity and various functional CNS anomalies are other frequent complications. Cranial vault expansion and reconstructive surgery remain the mainstay of treatment but pose an elevated risk of morbidity for the infant. While the etiology of nonsyndromic craniosynostosis remains to be deciphered, gain-of-function mutations in
Identifiants
pubmed: 30976284
doi: 10.1159/000493535
pii: msy-0010-0115
pmc: PMC6422115
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
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