Dendritic Cells and Cancer: From Biology to Therapeutic Intervention.
DC-based therapy
cancer
checkpoint blockade
immunosuppression
immunotherapy
novel therapies
tumor-associated dendritic cells
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
11 Apr 2019
11 Apr 2019
Historique:
received:
08
03
2019
revised:
05
04
2019
accepted:
07
04
2019
entrez:
14
4
2019
pubmed:
14
4
2019
medline:
14
4
2019
Statut:
epublish
Résumé
Inducing effective anti-tumor immunity has become a major therapeutic strategy against cancer. Dendritic cells (DC) are a heterogenous population of antigen presenting cells that infiltrate tumors. While DC play a critical role in the priming and maintenance of local immunity, their functions are often diminished, or suppressed, by factors encountered in the tumor microenvironment. Furthermore, DC populations with immunosuppressive activities are also recruited to tumors, limiting T cell infiltration and promoting tumor growth. Anti-cancer therapies can impact the function of tumor-associated DC and/or alter their phenotype. Therefore, the design of effective anti-cancer therapies for clinical translation should consider how best to boost tumor-associated DC function to drive anti-tumor immunity. In this review, we discuss the different subsets of tumor-infiltrating DC and their role in anti-tumor immunity. Moreover, we describe strategies to enhance DC function within tumors and harness these cells for effective tumor immunotherapy.
Identifiants
pubmed: 30979057
pii: cancers11040521
doi: 10.3390/cancers11040521
pmc: PMC6521027
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Cancer Council Western Australia
ID : N/A
Organisme : Australian Research Council
ID : Future Fellowship (FT180100521)
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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