Probiotics: If It Does Not Help It Does Not Do Any Harm. Really?
probiotics, autoimmune disease, horizontal gene transfer, virulent factor, antibiotic-resistant genes, public health
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
11 Apr 2019
11 Apr 2019
Historique:
received:
26
03
2019
revised:
06
04
2019
accepted:
09
04
2019
entrez:
14
4
2019
pubmed:
14
4
2019
medline:
14
4
2019
Statut:
epublish
Résumé
Probiotics per definition should have beneficial effects on human health, and their consumption has tremendously increased in the last decades. In parallel, the amount of published material and claims for their beneficial efficacy soared continuously. Recently, multiple systemic reviews, meta-analyses, and expert opinions expressed criticism on their claimed effects and safety. The present review describes the dark side of the probiotics, in terms of problematic research design, incomplete reporting, lack of transparency, and under-reported safety. Highlighted are the potential virulent factors and the mode of action in the intestinal lumen, risking the physiological microbiome equilibrium. Finally, regulatory topics are discussed to lighten the heterogeneous guidelines applied worldwide. The shift in the scientific world towards a better understanding of the human microbiome, before consumption of the probiotic cargo, is highly endorsed. It is hoped that better knowledge will extend the probiotic repertoire, re-confirm efficacy or safety, establish their efficacy and substantiate their beneficial effects.
Identifiants
pubmed: 30979072
pii: microorganisms7040104
doi: 10.3390/microorganisms7040104
pmc: PMC6517882
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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