Characteristics, risk factors and outcomes of Clostridium difficile infections in Greek Intensive Care Units.
APACHE
Aged
Aged, 80 and over
Clostridioides difficile
/ drug effects
Clostridium Infections
/ classification
Cohort Studies
Female
Greece
Humans
Male
Middle Aged
Organ Dysfunction Scores
Outcome Assessment, Health Care
/ methods
Prospective Studies
Retrospective Studies
Risk Factors
Severity of Illness Index
C. difficile
Critically-ill
ICU
Mortality
Journal
Intensive & critical care nursing
ISSN: 1532-4036
Titre abrégé: Intensive Crit Care Nurs
Pays: Netherlands
ID NLM: 9211274
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
25
07
2018
revised:
15
03
2019
accepted:
19
03
2019
pubmed:
14
4
2019
medline:
20
12
2019
entrez:
14
4
2019
Statut:
ppublish
Résumé
Clostridium difficile is one of the major causes of diarrhoea among critically ill patients and its prevalence increases exponentially in relation to the use of antibiotics and medical devices. We sought to investigate the incidence of C. difficile infection in Greek units, and identify potential risk factors related to C. difficile infection. A prospective multicenter cohort analysis of critically ill patients (3 ICUs from 1/1/2014 to 31/12/2014). Among 970(100%) patients, 95(9.79%) with diarrhoea, were included. Their demographic, comorbidity and clinical characteristics were recorded on admission to the unit. The known predisposing factors for the infection were recorded and the diagnostic tests to confirm C. difficile were conducted, based on the current guidelines. The incidence of C. difficile infection was 1.3% (n = 13). All-cause mortality in patients with diarrhoea, C. difficile infection and attributable mortality in patients with C. difficile infection was 28%, 38.5% and 30.8% respectively. Sequential Organ Failure Assessment (SOFA) scores on admission were significantly lower and prior C. difficile infection was more common in patients with current C. difficile infection. Regarding other potential risk factors, no difference was found between groups. No factor was independently associated with C. difficile infection. C. difficile infection is low in Greek intensive care units, but remains a serious problem among the critically-ill. Mortality was similar to reports from other countries. No factor was independently associated with C. difficile infection.
Sections du résumé
BACKGROUND
BACKGROUND
Clostridium difficile is one of the major causes of diarrhoea among critically ill patients and its prevalence increases exponentially in relation to the use of antibiotics and medical devices. We sought to investigate the incidence of C. difficile infection in Greek units, and identify potential risk factors related to C. difficile infection.
METHODS
METHODS
A prospective multicenter cohort analysis of critically ill patients (3 ICUs from 1/1/2014 to 31/12/2014).
RESULTS
RESULTS
Among 970(100%) patients, 95(9.79%) with diarrhoea, were included. Their demographic, comorbidity and clinical characteristics were recorded on admission to the unit. The known predisposing factors for the infection were recorded and the diagnostic tests to confirm C. difficile were conducted, based on the current guidelines. The incidence of C. difficile infection was 1.3% (n = 13). All-cause mortality in patients with diarrhoea, C. difficile infection and attributable mortality in patients with C. difficile infection was 28%, 38.5% and 30.8% respectively. Sequential Organ Failure Assessment (SOFA) scores on admission were significantly lower and prior C. difficile infection was more common in patients with current C. difficile infection. Regarding other potential risk factors, no difference was found between groups. No factor was independently associated with C. difficile infection.
CONCLUSIONS
CONCLUSIONS
C. difficile infection is low in Greek intensive care units, but remains a serious problem among the critically-ill. Mortality was similar to reports from other countries. No factor was independently associated with C. difficile infection.
Identifiants
pubmed: 30979531
pii: S0964-3397(18)30241-6
doi: 10.1016/j.iccn.2019.03.008
pii:
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Pagination
73-78Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.