TAM receptors in cardiovascular disease.

Animals Cardiovascular Diseases / enzymology Cardiovascular System / enzymology Humans Ligands Proto-Oncogene Proteins / metabolism Receptor Protein-Tyrosine Kinases / metabolism Signal Transduction c-Mer Tyrosine Kinase / metabolism Axl Receptor Tyrosine Kinase
Axl Cardiovascular disease MerTK TAM receptors Tyro3

Journal

Cardiovascular research
ISSN: 1755-3245
Titre abrégé: Cardiovasc Res
Pays: England
ID NLM: 0077427

Informations de publication

Date de publication:
01 07 2019
Historique:
received: 04 01 2019
revised: 28 02 2019
accepted: 09 04 2019
pubmed: 14 4 2019
medline: 17 6 2020
entrez: 14 4 2019
Statut: ppublish

Résumé

The TAM receptors are a distinct family of three receptor tyrosine kinases, namely Tyro3, Axl, and MerTK. Since their discovery in the early 1990s, they have been studied for their ability to influence numerous diseases, including cancer, chronic inflammatory and autoimmune disorders, and cardiovascular diseases. The TAM receptors demonstrate an ability to influence multiple aspects of cardiovascular pathology via their diverse effects on cells of both the vasculature and the immune system. In this review, we will explore the various functions of the TAM receptors and how they influence cardiovascular disease through regulation of vascular remodelling, efferocytosis and inflammation. Based on this information, we will suggest areas in which further research is required and identify potential targets for therapeutic intervention.

Identifiants

DOI: 10.1093/cvr/cvz100 PMID: 30980657 PMC: PMC6587925
pubmed: 30980657
pii: 5454688
doi: 10.1093/cvr/cvz100
pmc: PMC6587925
doi:

Substances chimiques

Ligands 0
Proto-Oncogene Proteins 0
MERTK protein, human EC 2.7.10.1
Receptor Protein-Tyrosine Kinases EC 2.7.10.1
TYRO3 protein, human EC 2.7.10.1
c-Mer Tyrosine Kinase EC 2.7.10.1
Axl Receptor Tyrosine Kinase 0
AXL protein, human 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1286-1295

Subventions

Organisme : British Heart Foundation
ID : RE/13/5/30177
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/16/55/32731
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL127464
Pays : United States
Organisme : British Heart Foundation
ID : PG/12/81/29897
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : P01 HL087123
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL145228
Pays : United States
Organisme : Arthritis Research UK
ID : RACE20298
Pays : United Kingdom

Informations de copyright

© The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology.

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Auteurs

Lucy McShane (L)

Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Sir Graeme Davies Building, 120 University Place, Glasgow, UK.
Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

Ira Tabas (I)

Departments of Medicine, Physiology, and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.

Greg Lemke (G)

Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Immunobiology and Microbial Pathogenesis Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.

Mariola Kurowska-Stolarska (M)

Rheumatoid Arthritis Pathogenesis Centre of Excellence (RACE), Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Sir Graeme Davies Building, 120 University Place, Glasgow, UK.

Pasquale Maffia (P)

Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Sir Graeme Davies Building, 120 University Place, Glasgow, UK.
Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Department of Pharmacy, University of Naples Federico II, Naples, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › TAM receptors in cardiovascular disease.
questionsmedicales.fr › Maladies cardiovasculaires › TAM receptors in cardiovascular disease.
questionsmedicales.fr › Système cardiovasculaire › TAM receptors in cardiovascular disease.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › TAM receptors in cardiovascular disease.
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › TAM receptors in cardiovascular disease.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › TAM receptors in cardiovascular disease.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs à activité tyrosine kinase › TAM receptors in cardiovascular disease.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › TAM receptors in cardiovascular disease.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › c-Mer Tyrosine kinase › TAM receptors in cardiovascular disease.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Axl Receptor Tyrosine Kinase › TAM receptors in cardiovascular disease.