Expanding the activity spectrum of antiviral agents.

Animals Antiviral Agents / chemistry Drug Discovery Drug Repositioning Humans Viruses / drug effects

Journal

Drug discovery today
ISSN: 1878-5832
Titre abrégé: Drug Discov Today
Pays: England
ID NLM: 9604391

Informations de publication

Date de publication:
05 2019
Historique:
received: 02 03 2019
revised: 02 04 2019
accepted: 05 04 2019
pubmed: 14 4 2019
medline: 18 1 2020
entrez: 14 4 2019
Statut: ppublish

Résumé

Broad-spectrum antivirals (BSAs) are agents that inhibit replication of several human viruses. Here, we review 108 approved, investigational, and experimental BSAs, for which safety profiles in humans are available. The most effective and tolerable BSAs could reinforce the arsenal of available antiviral therapeutics pending the results of further pre-clinical and clinical studies.

Identifiants

DOI: 10.1016/j.drudis.2019.04.006 PMID: 30980905
pubmed: 30980905
pii: S1359-6446(18)30538-5
doi: 10.1016/j.drudis.2019.04.006
pii:
doi:

Substances chimiques

Antiviral Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1224-1228

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Aleksandr Ianevski (A)

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim 7028, Norway.

Petter I Andersen (PI)

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim 7028, Norway.

Andres Merits (A)

Institute of Technology, University of Tartu, Tartu 50090, Estonia.

Magnar Bjørås (M)

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim 7028, Norway; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo 0027, Norway.

Denis Kainov (D)

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim 7028, Norway; Institute of Technology, University of Tartu, Tartu 50090, Estonia. Electronic address: denis.kainov@ntnu.no.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Expanding the activity spectrum of antiviral agents.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Expanding the activity spectrum of antiviral agents.
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Expanding the activity spectrum of antiviral agents.
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Repositionnement des médicaments › Expanding the activity spectrum of antiviral agents.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Expanding the activity spectrum of antiviral agents.
questionsmedicales.fr › Virus › Expanding the activity spectrum of antiviral agents.