Atractyligenin, a terpenoid isolated from coffee silverskin, inhibits cutaneous photoaging.

Atractyloside / analogs & derivatives Cell Survival / drug effects Coffee / chemistry Down-Regulation / drug effects Gene Expression Regulation / drug effects Humans JNK Mitogen-Activated Protein Kinases / metabolism Matrix Metalloproteinases / metabolism Mitogen-Activated Protein Kinases / metabolism Phosphorylation / drug effects Reactive Oxygen Species / metabolism Skin Aging / drug effects
Atractyligenin Coffee silverskin Endo180 Matrix metalloproteases Photoaging

Journal

Journal of photochemistry and photobiology. B, Biology
ISSN: 1873-2682
Titre abrégé: J Photochem Photobiol B
Pays: Switzerland
ID NLM: 8804966

Informations de publication

Date de publication:
May 2019
Historique:
received: 14 01 2019
revised: 29 03 2019
accepted: 03 04 2019
pubmed: 14 4 2019
medline: 5 6 2019
entrez: 14 4 2019
Statut: ppublish

Résumé

Ultraviolet (UV) light exposure-induced photoaging of the skin is a multifactorial process involving both extrinsic and intrinsic cellular mechanisms. Several naturally occurring products are known to confer protection against UV light-induced skin damage. Our preliminary studies confirmed that the ethyl acetate fraction of coffee silverskin exhibits inhibitory effects on matrix metalloproteases (MMPs). Furthermore, we previously isolated and identified atractyligenin, which has MMP-inhibitory activity, from the silverskin ethyl acetate fraction. The aim of this study was to elucidate the anti-photoaging effects of atractyligenin on human dermal fibroblasts and the underlying mechanism. Human dermal fibroblasts were exposed to 8 J/cm

Identifiants

DOI: 10.1016/j.jphotobiol.2019.04.002 PMID: 30981089
pubmed: 30981089
pii: S1011-1344(19)30044-2
doi: 10.1016/j.jphotobiol.2019.04.002
pii:
doi:

Substances chimiques

Coffee 0
Reactive Oxygen Species 0
atractyligenine 0
Atractyloside 17754-44-8
JNK Mitogen-Activated Protein Kinases EC 2.7.11.24
Mitogen-Activated Protein Kinases EC 2.7.11.24
Matrix Metalloproteinases EC 3.4.24.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

166-173

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Song Hua Xuan (SH)

Department of Fine Chemistry, Cosmetic Industry Coupled Collaboration Center, Cosmetic R&D Center, Seoul National University of Science and Technology, 232 Gongneung-ro, Nowon-gu, Seoul 01811, Republic of Korea.

Nam Ho Lee (NH)

Department of Chemistry and Cosmetics, College of Natural Sciences, Jeju National University, Jeju 63243, Republic of Korea.

Soo Nam Park (SN)

Department of Fine Chemistry, Cosmetic Industry Coupled Collaboration Center, Cosmetic R&D Center, Seoul National University of Science and Technology, 232 Gongneung-ro, Nowon-gu, Seoul 01811, Republic of Korea. Electronic address: snpark@seoultech.ac.kr.

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Classifications MeSH

questionsmedicales.fr › Glucides › Hétérosides › Atractyloside › Atractyligenin, a terpenoid isolated from...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Atractyligenin, a terpenoid isolated from...
questionsmedicales.fr › Aliments et boissons › Boissons › Café › Atractyligenin, a terpenoid isolated from...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation négative › Atractyligenin, a terpenoid isolated from...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Atractyligenin, a terpenoid isolated from...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Atractyligenin, a terpenoid isolated from...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › JNK Mitogen-Activated Protein Kinases › Atractyligenin, a terpenoid isolated from...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Metalloproteases › Metalloendopeptidases › Matrix metalloproteinases › Atractyligenin, a terpenoid isolated from...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › Atractyligenin, a terpenoid isolated from...
questionsmedicales.fr › Métabolisme › Phosphorylation › Atractyligenin, a terpenoid isolated from...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Atractyligenin, a terpenoid isolated from...
questionsmedicales.fr › Phénomènes physiologiques du système tégumentaire › Phénomènes physiologiques de la peau › Vieillissement de la peau › Atractyligenin, a terpenoid isolated from...