Non anti-HLA antibodies and acute rejection: A critical viewpoint
Anticorps non-HLA et transplantation d’organe : une vision critique.
Agression endothéliale
Anti-endothelial cell antibody
Anticorps anticellules endothéliales
Anticorps non-HLA
Endothelial injury
Non-HLA antibody
Rejection
Rejet
Transplantation
Journal
Nephrologie & therapeutique
ISSN: 1872-9177
Titre abrégé: Nephrol Ther
Pays: France
ID NLM: 101248950
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
28
01
2019
accepted:
04
03
2019
entrez:
15
4
2019
pubmed:
15
4
2019
medline:
15
4
2019
Statut:
ppublish
Résumé
In solid organ transplantation, the deleterious effect of antibodies directed against donor HLA antigens, whether preformed or de novo, is well established. Anti-HLA antibodies have been associated not only with the risk of antibody-mediated rejection but also with late graft dysfunction and are now considered to be the leading cause of allograft loss after renal transplantation. In addition to HLA antibodies, the possible involvement of non-HLA antibodies targeting donor endothelial cells has long been the subject of intense research. The purpose of this review is to discuss current knowledge and remaining issues related to the involvement of non-HLA antibodies in solid organ transplantation. More specifically, the clinical data underlying the hypothesis of the role of non-HLA antibodies will be discussed, as well as the different techniques for antibody detection, their clinical relevance and their antigenic targets.
Identifiants
pubmed: 30981396
pii: S1769-7255(19)30042-2
doi: 10.1016/j.nephro.2019.03.003
pii:
doi:
Types de publication
English Abstract
Journal Article
Langues
fre
Pagination
S53-S59Informations de copyright
Copyright © 2019 Société francophone de néphrologie, dialyse et transplantation. Published by Elsevier Masson SAS. All rights reserved.