Crystalline sponge-laser desorption ionization (CS-LDI) of unsaturated cyclic organic compounds encapsulated in different electronic environments in pores.

We have developed laser desorption ionization mass spectrometry (LDI-MS) of organic molecules encapsulated in a crystalline sponge (CS). Cyclic organic compounds 1,2,3,4,5-pentamethylcyclopentadiene, zerumbone, and muscone were encapsulated in CS as guest regardless of guest crystallization. Single-crystal X-ray analysis closely scrutinized the position of the guest in the pore and the interaction between the guest and the CS framework. After single-crystal X-ray analysis, the same single crystal was subjected to LDI-MS. Ionization efficiency differed markedly depending on whether π-π interaction existed or not. It is obvious that π-π interaction is the key to transferring laser energy from the CS framework to the guest for the ionization of molecule encapsulated in CS. The results suggest the importance of controlling the positions of analyte and matrix as well as noncovalent interactions, such as hydrogen bonding interaction, electrostatic interaction, and so on.

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.