Emotional Mirror Neurons in the Rat's Anterior Cingulate Cortex.
causality
emotional contagion
empathy
fear
mirror neurons
pain
rodent
social behavior
vicarious activity
Journal
Current biology : CB
ISSN: 1879-0445
Titre abrégé: Curr Biol
Pays: England
ID NLM: 9107782
Informations de publication
Date de publication:
22 04 2019
22 04 2019
Historique:
received:
01
12
2018
revised:
11
03
2019
accepted:
14
03
2019
pubmed:
16
4
2019
medline:
19
5
2020
entrez:
16
4
2019
Statut:
ppublish
Résumé
How do the emotions of others affect us? The human anterior cingulate cortex (ACC) responds while experiencing pain in the self and witnessing pain in others, but the underlying cellular mechanisms remain poorly understood. Here we show the rat ACC (area 24) contains neurons responding when a rat experiences pain as triggered by a laser and while witnessing another rat receive footshocks. Most of these neurons do not respond to a fear-conditioned sound (CS). Deactivating this region reduces freezing while witnessing footshocks to others but not while hearing the CS. A decoder trained on spike counts while witnessing footshocks to another rat can decode stimulus intensity both while witnessing pain in another and while experiencing the pain first-hand. Mirror-like neurons thus exist in the ACC that encode the pain of others in a code shared with first-hand pain experience. A smaller population of neurons responded to witnessing footshocks to others and while hearing the CS but not while experiencing laser-triggered pain. These differential responses suggest that the ACC may contain channels that map the distress of another animal onto a mosaic of pain- and fear-sensitive channels in the observer. More experiments are necessary to determine whether painfulness and fearfulness in particular or differences in arousal or salience are responsible for these differential responses.
Identifiants
pubmed: 30982647
pii: S0960-9822(19)30322-7
doi: 10.1016/j.cub.2019.03.024
pmc: PMC6488290
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1301-1312.e6Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Ltd.. All rights reserved.
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