Viral suppression among children and their caregivers living with HIV in western Kenya.
HIV
adherence
caregiver
child
sub-Saharan Africa
viraemia
Journal
Journal of the International AIDS Society
ISSN: 1758-2652
Titre abrégé: J Int AIDS Soc
Pays: Switzerland
ID NLM: 101478566
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
17
09
2018
accepted:
12
03
2019
entrez:
16
4
2019
pubmed:
16
4
2019
medline:
14
4
2020
Statut:
ppublish
Résumé
Despite the central role of caregivers in managing HIV treatment for children living with HIV, viral suppression within caregiver-child dyads in which both members are living with HIV is not well described. We conducted a retrospective analysis of children living with HIV <15 years of age and their caregivers living with HIV attending HIV clinics affiliated with the Academic Model Providing Access to Healthcare (AMPATH) in Kenya between 2015 and 2017. To be included in the analysis, children and caregivers must have had ≥1 viral load (VL) during the study period while receiving antiretroviral therapy (ART) for ≥6 months, and the date of the caregiver's VL must have occurred ±90 days from the date of the child's VL. The characteristics of children, caregivers and dyads were descriptively summarized. Multivariable logistic regression was used to estimate the odds of viral non-suppression (≥ 1000 copies/mL) in children, adjusting for caregiver and child characteristics. Of 7667 children who received care at AMPATH during the study period, 1698 were linked to a caregiver living with HIV and included as caregiver-child dyads. For caregivers, 94% were mothers, median age at ART initiation 32.8 years, median CD4 count at ART initiation 164 cells/mm Children were at higher risk of viral non-suppression if their caregivers were not virally suppressed compared to children with suppressed caregivers. A child's viral suppression status should be closely monitored if his or her caregiver is not suppressed.
Identifiants
pubmed: 30983148
doi: 10.1002/jia2.25272
pmc: PMC6462809
doi:
Substances chimiques
Anti-HIV Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e25272Subventions
Organisme : NIAID NIH HHS
ID : P30 AI042853
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI069911
Pays : United States
Organisme : NIH HHS
ID : U01AI069911
Pays : United States
Informations de copyright
© 2019 The Authors. Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of the International AIDS Society.
Références
J Int AIDS Soc. 2017 Mar 22;20(1):21371
pubmed: 28630651
Curr HIV/AIDS Rep. 2009 Nov;6(4):194-200
pubmed: 19849962
Glob Pediatr Health. 2018 Nov 14;5:2333794X18811795
pubmed: 30542658
AIDS. 2013 Oct 23;27(16):2567-75
pubmed: 23842124
Ann Trop Paediatr. 2007 Jun;27(2):123-31
pubmed: 17565809
AIDS. 2009 Jan 14;23(2):195-201
pubmed: 19098489
Pediatr Infect Dis J. 2008 Aug;27(8):686-91
pubmed: 18574439
Open Forum Infect Dis. 2014 Sep 09;1(2):ofu079
pubmed: 25734147
J Int AIDS Soc. 2017 Jul 21;20(Suppl 4):21649
pubmed: 28770595
Curr Opin HIV AIDS. 2008 Jul;3(4):461-7
pubmed: 19373006
AIDS. 2007 Dec;21 Suppl 8:S157-61
pubmed: 18172385
J Acquir Immune Defic Syndr. 2008 Apr 15;47(5):566-9
pubmed: 18197120
AIDS Care. 2018 Jun;30(6):701-705
pubmed: 29058461
Health Policy. 2010 Dec;98(2-3):121-30
pubmed: 20591529
Trop Med Int Health. 2009 Feb;14(2):204-12
pubmed: 19236666
Lancet Child Adolesc Health. 2017 Nov;1(3):175-183
pubmed: 29104904
Clin Infect Dis. 2016 Dec 15;63(12):1645-1654
pubmed: 27660236
AIDS Care. 2010 Mar;22(3):271-8
pubmed: 20390506
Lancet HIV. 2017 Aug;4(8):e323-e324
pubmed: 28495563
Soc Sci Med. 2005 Dec;61(11):2423-33
pubmed: 15936134
PLoS One. 2018 Mar 9;13(3):e0192068
pubmed: 29522530
J Int AIDS Soc. 2019 Apr;22(4):e25272
pubmed: 30983148
AIDS. 2011 Jan 2;25(1):49-55
pubmed: 20935555
Clin Infect Dis. 2015 Nov 1;61(9):1453-61
pubmed: 26157050
J Int AIDS Soc. 2014 Nov 25;17:19227
pubmed: 25427633
Pan Afr Med J. 2018 Jun 27;30:178
pubmed: 30455807
AIDS. 2016 Nov 28;30(18):2835-2843
pubmed: 27603293
J Acquir Immune Defic Syndr. 2011 Apr;56(4):333-9
pubmed: 21239995
BMC Pediatr. 2010 Aug 06;10:56
pubmed: 20691045
J Med Virol. 2005 Feb;75(2):202-8
pubmed: 15602734
Qual Health Res. 2009 Dec;19(12):1716-29
pubmed: 19949221
J Infect Dis. 2013 Jun 15;207 Suppl 2:S85-92
pubmed: 23687294
AIDS. 2014 Oct 23;28(16):2395-405
pubmed: 25389551
MMWR Morb Mortal Wkly Rep. 2015 Nov 27;64(46):1287-90
pubmed: 26605986
J Acquir Immune Defic Syndr. 2014 Dec 1;67 Suppl 4:S243-9
pubmed: 25436824
AIDS. 2015 Jun;29 Suppl 1:S57-65
pubmed: 26049539
AIDS Behav. 2016 May;20(5):1076-83
pubmed: 26443264
Int J Epidemiol. 2012 Oct;41(5):1256-64
pubmed: 21593078
J Health Care Poor Underserved. 2009;20(4 Suppl):36-40
pubmed: 20168031
Stat Med. 2004 Mar 30;23(6):859-74; discussion 875-7,879-80
pubmed: 15027075
Expert Opin Pharmacother. 2009 Dec;10(17):2773-8
pubmed: 19929700
PLoS Med. 2017 Apr 18;14(4):e1002278
pubmed: 28419097
Trop Med Int Health. 2009 Jun;14(6):663-72
pubmed: 19392748
J Acquir Immune Defic Syndr. 2012 Oct 1;61(2):158-163
pubmed: 22692090
Curr HIV/AIDS Rep. 2018 Apr;15(2):136-146
pubmed: 29504062
J Int AIDS Soc. 2010 Jun 23;13 Suppl 2:S1
pubmed: 20573283
Pediatr Infect Dis J. 2013 May;32(5):489-94
pubmed: 23249913
JAMA Pediatr. 2015 May;169(5):498-500
pubmed: 25822083
PLoS One. 2018 Jan 11;13(1):e0190659
pubmed: 29324811
J Int AIDS Soc. 2017 Apr 25;20(1):21362
pubmed: 28453240
Pediatr Infect Dis J. 2011 Nov;30(11):974-9
pubmed: 21734620
PLoS One. 2018 Feb 21;13(2):e0191848
pubmed: 29466385
J Acquir Immune Defic Syndr. 2017 May 1;75(1):18-26
pubmed: 28114186
AIDS Care. 2015;27(3):322-6
pubmed: 25338010
Stud Health Technol Inform. 2007;129(Pt 1):372-6
pubmed: 17911742
AIDS Patient Care STDS. 2010 Mar;24(3):147-58
pubmed: 20214482
Acad Med. 2007 Aug;82(8):812-8
pubmed: 17762264