Systemic Redox Imbalance Along with Increased Serum Sialic Acid is Prevalent in Patients with Active Vitiligo: A Study from a Tertiary Care Teaching Hospital of Eastern India.
Active vitiligo
malondialdehyde
redox imbalance
serum sialic acid
superoxide dismutase
Journal
Indian journal of dermatology
ISSN: 1998-3611
Titre abrégé: Indian J Dermatol
Pays: India
ID NLM: 0370750
Informations de publication
Date de publication:
Historique:
entrez:
16
4
2019
pubmed:
16
4
2019
medline:
16
4
2019
Statut:
ppublish
Résumé
Vitiligo is one of the common depigmenting disorders causing disfigurement and affecting the quality of life. Redox imbalance is known to play a contributory role in melanocyte destruction. Serum sialic acid (SA) is an important marker of the acute-phase response and is associated with oxidative protein damage. The aim of this study was to analyze the status of oxidative stress markers and serum SA in vitiligo patients and to correlate the same with disease activity. The different oxidative stress parameters namely superoxide dismutase (SOD), malondialdehyde (MDA), and serum SA were measured spectrophotometrically using standard biochemical methodologies in all the study subjects. Serum SOD and MDA values were higher in patients with active vitiligo ( This study indicates that patients with active vitiligo demonstrate enhanced MDA/SOD ratio and increased serum SA. The studied parameters can serve as an important tool to monitor disease activity in vitiligo.
Sections du résumé
BACKGROUND
BACKGROUND
Vitiligo is one of the common depigmenting disorders causing disfigurement and affecting the quality of life. Redox imbalance is known to play a contributory role in melanocyte destruction. Serum sialic acid (SA) is an important marker of the acute-phase response and is associated with oxidative protein damage.
AIM
OBJECTIVE
The aim of this study was to analyze the status of oxidative stress markers and serum SA in vitiligo patients and to correlate the same with disease activity.
MATERIALS AND METHODS
METHODS
The different oxidative stress parameters namely superoxide dismutase (SOD), malondialdehyde (MDA), and serum SA were measured spectrophotometrically using standard biochemical methodologies in all the study subjects.
RESULTS
RESULTS
Serum SOD and MDA values were higher in patients with active vitiligo (
CONCLUSION
CONCLUSIONS
This study indicates that patients with active vitiligo demonstrate enhanced MDA/SOD ratio and increased serum SA. The studied parameters can serve as an important tool to monitor disease activity in vitiligo.
Identifiants
pubmed: 30983603
doi: 10.4103/ijd.IJD_448_17
pii: IJD-64-97
pmc: PMC6440190
doi:
Types de publication
Journal Article
Langues
eng
Pagination
97-100Déclaration de conflit d'intérêts
There are no conflicts of interest.
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