Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development.
CNS
adenosine receptors
inflammation
pain
purinergic signaling
Journal
Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935
Informations de publication
Date de publication:
2019
2019
Historique:
received:
08
01
2019
accepted:
13
03
2019
entrez:
16
4
2019
pubmed:
16
4
2019
medline:
16
4
2019
Statut:
epublish
Résumé
Adenosine receptors (ARs) function in the body's response to conditions of pathology and stress associated with a functional imbalance, such as in the supply and demand of energy/oxygen/nutrients. Extracellular adenosine concentrations vary widely to raise or lower the basal activation of four subtypes of ARs. Endogenous adenosine can correct an energy imbalance during hypoxia and other stress, for example, by slowing the heart rate by A
Identifiants
pubmed: 30983976
doi: 10.3389/fncel.2019.00124
pmc: PMC6447611
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
124Subventions
Organisme : Intramural NIH HHS
ID : ZIA DK031117
Pays : United States
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