Microvascular bioengineering: a focus on pericytes.
Capillary
Computational modeling
Endothelial cells
Microfluidics
Pericytes
Journal
Journal of biological engineering
ISSN: 1754-1611
Titre abrégé: J Biol Eng
Pays: England
ID NLM: 101306640
Informations de publication
Date de publication:
2019
2019
Historique:
received:
03
12
2018
accepted:
15
03
2019
entrez:
16
4
2019
pubmed:
16
4
2019
medline:
16
4
2019
Statut:
epublish
Résumé
Capillaries within the microcirculation are essential for oxygen delivery and nutrient/waste exchange, among other critical functions. Microvascular bioengineering approaches have sought to recapitulate many key features of these capillary networks, with an increasing appreciation for the necessity of incorporating vascular pericytes. Here, we briefly review established and more recent insights into important aspects of pericyte identification and function within the microvasculature. We then consider the importance of including vascular pericytes in various bioengineered microvessel platforms including 3D culturing and microfluidic systems. We also discuss how vascular pericytes are a vital component in the construction of computational models that simulate microcirculation phenomena including angiogenesis, microvascular biomechanics, and kinetics of exchange across the vessel wall. In reviewing these topics, we highlight the notion that incorporating pericytes into microvascular bioengineering applications will increase their utility and accelerate the translation of basic discoveries to clinical solutions for vascular-related pathologies.
Identifiants
pubmed: 30984287
doi: 10.1186/s13036-019-0158-3
pii: 158
pmc: PMC6444752
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
26Subventions
Organisme : NHLBI NIH HHS
ID : R00 HL105779
Pays : United States
Organisme : NHLBI NIH HHS
ID : R56 HL133826
Pays : United States
Déclaration de conflit d'intérêts
Not applicable.Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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