Rational Design of Antiangiogenic Helical Oligopeptides Targeting the Vascular Endothelial Growth Factor Receptors.
Cα,α-disubstituted amino acids
VEGF-C
angiogenesis
helical folded peptides
protein-protein interactions
Journal
Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988
Informations de publication
Date de publication:
2019
2019
Historique:
received:
11
01
2019
accepted:
05
03
2019
entrez:
16
4
2019
pubmed:
16
4
2019
medline:
16
4
2019
Statut:
epublish
Résumé
Tumor angiogenesis, essential for cancer development, is regulated mainly by vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs), which are overexpressed in cancer cells. Therefore, the VEGF/VEGFR interaction represents a promising pharmaceutical target to fight cancer progression. The VEGF surface interacting with VEGFRs comprises a short α-helix. In this work, helical oligopeptides mimicking the VEGF-C helix were rationally designed based on structural analyses and computational studies. The helical conformation was stabilized by optimizing intramolecular interactions and by introducing helix-inducing C
Identifiants
pubmed: 30984741
doi: 10.3389/fchem.2019.00170
pmc: PMC6449863
doi:
Types de publication
Journal Article
Langues
eng
Pagination
170Références
Proc Soc Exp Biol Med. 1999 Nov;222(2):124-38
pubmed: 10564536
J Biol Chem. 2000 Sep 22;275(38):29823-8
pubmed: 10878003
J Cell Sci. 2001 Mar;114(Pt 5):853-65
pubmed: 11181169
Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10037-41
pubmed: 11517324
Biopolymers. 2001;60(6):396-419
pubmed: 12209474
Nat Med. 2003 Jun;9(6):669-76
pubmed: 12778165
Biophys J. 2003 Jul;85(1):159-66
pubmed: 12829472
J Biol Chem. 2003 Sep 12;278(37):35564-73
pubmed: 12837752
Proteins. 2004 May 1;55(2):383-94
pubmed: 15048829
Nat Rev Drug Discov. 2004 May;3(5):391-400
pubmed: 15136787
Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W665-7
pubmed: 15215472
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
J Comput Chem. 2004 Oct;25(13):1656-76
pubmed: 15264259
Biochemistry. 2004 Oct 19;43(41):13225-32
pubmed: 15476416
Pharmacol Rev. 2004 Dec;56(4):549-80
pubmed: 15602010
Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W382-8
pubmed: 15980494
Nat Rev Mol Cell Biol. 2006 May;7(5):359-71
pubmed: 16633338
Proteins. 2006 Nov 15;65(3):712-25
pubmed: 16981200
Br J Cancer. 2007 Feb 26;96(4):541-5
pubmed: 17164762
J Chem Phys. 2007 Jan 7;126(1):014101
pubmed: 17212484
Anal Biochem. 2007 Jul 1;366(1):108-10
pubmed: 17482136
J Am Chem Soc. 2008 Apr 30;130(17):5744-52
pubmed: 18386897
Phys Chem Chem Phys. 2008 Apr 21;10(15):2073-7
pubmed: 18688361
Angiogenesis. 2009;12(2):177-85
pubmed: 19267251
J Pept Sci. 2009 Sep;15(9):615-9
pubmed: 19399781
Br J Pharmacol. 2009 May;157(2):220-33
pubmed: 19459844
Nat Rev Cancer. 2010 Jan;10(1):9-22
pubmed: 20029421
Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2425-30
pubmed: 20145116
J Med Chem. 2010 Jun 10;53(11):4428-40
pubmed: 20462213
Nucleic Acids Res. 2010 Jul;38(Web Server issue):W480-6
pubmed: 20511591
PLoS One. 2010 Aug 23;5(8):e12352
pubmed: 20808810
J Am Chem Soc. 2010 Sep 29;132(38):13176-8
pubmed: 20812686
J Chem Inf Model. 2011 Jan 24;51(1):69-82
pubmed: 21117705
J Med Chem. 2011 Mar 10;54(5):1391-400
pubmed: 21280635
Nat Rev Drug Discov. 2011 Jun;10(6):417-27
pubmed: 21629292
Proteins. 2011 Sep;79(9):2671-83
pubmed: 21735484
Mol Pharm. 2012 Nov 5;9(11):2961-73
pubmed: 22967287
J Med Chem. 2012 Dec 27;55(24):10797-822
pubmed: 23098265
Expert Opin Ther Targets. 2013 Jan;17(1):7-20
pubmed: 23121690
J Biochem. 2013 Jan;153(1):13-9
pubmed: 23172303
Int J Mol Sci. 2012 Dec 20;14(1):88-107
pubmed: 23344023
Org Biomol Chem. 2013 Mar 21;11(11):1896-905
pubmed: 23381088
J Pept Sci. 2013 Apr;19(4):214-9
pubmed: 23420665
Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):12960-5
pubmed: 23878260
Angiogenesis. 2014 Jul;17(3):471-94
pubmed: 24482243
ACS Comb Sci. 2014 May 12;16(5):250-8
pubmed: 24725184
Vasc Cell. 2014 May 21;6:11
pubmed: 25053992
Exp Biol Med (Maywood). 2015 Jun;240(6):718-24
pubmed: 25888649
Sci Transl Med. 2015 Oct 14;7(309):309ra165
pubmed: 26468327
ChemistryOpen. 2015 Oct;4(5):633-41
pubmed: 26491644
J Chem Theory Comput. 2008 Mar;4(3):435-47
pubmed: 26620784
Nat Rev Drug Discov. 2016 Jun;15(6):385-403
pubmed: 26775688
Sci Rep. 2016 Apr 04;6:24000
pubmed: 27039838
Trends Mol Med. 2017 Mar;23(3):282-292
pubmed: 28162910
J Econ Perspect. ;29(1):139-62
pubmed: 28441702
Med Res Rev. 2017 Nov;37(6):1231-1274
pubmed: 28643862
J Med Chem. 2018 Feb 22;61(4):1382-1414
pubmed: 28737935
Molecules. 2017 Oct 28;22(11):null
pubmed: 29143774
Pharmaceuticals (Basel). 2018 May 07;11(2):null
pubmed: 29735913
Neuro Oncol. 2018 Oct 9;20(11):1462-1474
pubmed: 29939339
Neuro Oncol. 2018 Oct 9;20(11):1421-1422
pubmed: 30137575
Arch Biochem Biophys. 2018 Dec 15;660:72-86
pubmed: 30336134
Biopolymers. 1983 Dec;22(12):2577-637
pubmed: 6667333
Protein Sci. 1994 May;3(5):843-52
pubmed: 8061613
Biochim Biophys Acta. 1997 Apr 4;1338(2):161-85
pubmed: 9128135
Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7192-7
pubmed: 9207067
J Biol Chem. 1998 May 1;273(18):11115-20
pubmed: 9556597
Biophys J. 1998 Jul;75(1):422-7
pubmed: 9649402