Dbz
Dmaoc
N,N-dimethylaminoxy carbonyl
chemical ligation
peptide coupling
protecting group
solid phase peptide synthesis
thioester
Journal
Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988
Informations de publication
Date de publication:
2019
2019
Historique:
received:
08
01
2019
accepted:
05
03
2019
entrez:
16
4
2019
pubmed:
16
4
2019
medline:
16
4
2019
Statut:
epublish
Résumé
Peptide coupling with minimal protection is one of the desired methods for the synthesis of peptides and proteins. To achieve regioselective amide bond formation, side chain protection is often essential; however, protecting groups potentially diminish peptide solubility and render the polar polyamide chain amphipathic due to their apolar nature. In this manuscript, we describe a new protecting group,
Identifiants
pubmed: 30984743
doi: 10.3389/fchem.2019.00173
pmc: PMC6447706
doi:
Types de publication
Journal Article
Langues
eng
Pagination
173Références
Biopolymers. 1999;51(4):247-65
pubmed: 10618594
J Org Chem. 2000 Dec 1;65(24):8210-3
pubmed: 11101375
J Biol Chem. 2006 Aug 18;281(33):23668-75
pubmed: 16766795
Angew Chem Int Ed Engl. 2006 Sep 4;45(35):5752-84
pubmed: 16948174
Angew Chem Int Ed Engl. 2008;47(36):6851-5
pubmed: 18651678
J Org Chem. 1977 Sep 30;42(20):3286-8
pubmed: 20489
Nature. 2011 Dec 21;480(7378):471-9
pubmed: 22193101
Curr Opin Struct Biol. 2014 Jun;26:16-23
pubmed: 24681507
Angew Chem Int Ed Engl. 2015 Feb 9;54(7):2194-8
pubmed: 25475965
Angew Chem Int Ed Engl. 2015 Jul 6;54(28):8226-30
pubmed: 26012897
Org Lett. 2016 Jan 15;18(2):164-7
pubmed: 26702477
Bioorg Med Chem. 2017 Sep 15;25(18):4926-4937
pubmed: 28687227
Acc Chem Res. 2017 Sep 19;50(9):2104-2115
pubmed: 28849903
Chemistry. 2018 Nov 27;24(66):17397-17404
pubmed: 29947435
Acc Chem Res. 2018 Jul 17;51(7):1643-1655
pubmed: 29979577