3D Hydrogels Containing Interconnected Microchannels of Subcellular Size for Capturing Human Pathogenic
Journal
ACS biomaterials science & engineering
ISSN: 2373-9878
Titre abrégé: ACS Biomater Sci Eng
Pays: United States
ID NLM: 101654670
Informations de publication
Date de publication:
08 Apr 2019
08 Apr 2019
Historique:
received:
24
08
2018
accepted:
10
01
2019
entrez:
16
4
2019
pubmed:
16
4
2019
medline:
16
4
2019
Statut:
ppublish
Résumé
Porous hydrogel scaffolds are ideal candidates for mimicking cellular microenvironments, regarding both structural and mechanical aspects. We present a novel strategy to use uniquely designed ceramic networks as templates for generating hydrogels with a network of interconnected pores in the form of microchannels. The advantages of this new approach are the high and guaranteed interconnectivity of the microchannels, as well as the possibility to produce channels with diameters smaller than 7 μm. Neither of these assets can be ensured with other established techniques. Experiments using the polyacrylamide substrates produced with our approach have shown that the migration of human pathogenic
Identifiants
pubmed: 30984820
doi: 10.1021/acsbiomaterials.8b01009
pmc: PMC6457568
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1784-1792Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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