Cancerous phenotypes associated with hypoxia-inducible factors are not influenced by the volatile anesthetic isoflurane in renal cell carcinoma.
Anesthetics, Inhalation
/ pharmacology
Carcinoma, Renal Cell
/ drug therapy
Cell Movement
/ drug effects
Cell Proliferation
/ drug effects
Gene Expression Regulation, Neoplastic
/ drug effects
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
/ genetics
Isoflurane
/ pharmacology
Kidney Neoplasms
/ drug therapy
Neovascularization, Pathologic
/ drug therapy
Phenotype
Tumor Cells, Cultured
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
08
11
2018
accepted:
26
03
2019
entrez:
16
4
2019
pubmed:
16
4
2019
medline:
7
1
2020
Statut:
epublish
Résumé
The possibility that anesthesia during cancer surgery may affect cancer recurrence, metastasis, and patient prognosis has become one of the most important topics of interest in cancer treatment. For example, the volatile anesthetic isoflurane was reported in several studies to induce hypoxia-inducible factors, and thereby enhance malignant phenotypes in vitro. Indeed, these transcription factors are considered critical regulators of cancer-related hallmarks, including "sustained proliferative signaling, evasion of growth suppressors, resistance to cell death, replicative immortality, angiogenesis, invasion, and metastasis." This study aimed to investigate the impact of isoflurane on the growth and migration of derivatives of the renal cell line RCC4. We indicated that isoflurane treatment did not positively influence cancer cell phenotypes, and that hypoxia-inducible factors (HIFs) maintain hallmark cancer cell phenotypes including gene expressions signature, metabolism, cell proliferation and cell motility. The present results indicate that HIF activity is not influenced by the volatile anesthetic isoflurane.
Identifiants
pubmed: 30986231
doi: 10.1371/journal.pone.0215072
pii: PONE-D-18-32256
pmc: PMC6464189
doi:
Substances chimiques
Anesthetics, Inhalation
0
HIF1A protein, human
0
Hypoxia-Inducible Factor 1, alpha Subunit
0
Isoflurane
CYS9AKD70P
Banques de données
figshare
['10.6084/m9.figshare.6571730']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0215072Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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